JAMA Medical News Associate Managing Editor Jennifer Abbasi talks with physician-geneticist Francis S. Collins, MD, PhD, as he steps down as director of the National Institutes of Health (NIH) and returns full-time to his laboratory at the National Human Genome Research Institute. Collins discusses the NIH’s biggest accomplishments and challenges during his historic tenure, shares what he will and won’t miss about the job, and much more. Related Content: After 12 Years, NIH Director Francis S. Collins Seeks His Next Chapter