In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Kevin B. Johnson, MD, MS, the David L. Cohen and Penn Integrates Knowledge University Professor of Pediatrics, Informatics, Engineering, and Communication at the University of Pennsylvania, discuss how AI can reduce clinician burden and streamline health system functions. Related Content: Electronic Health Records Failed to Make Clinicians’ Lives Easier—Will AI Technology Succeed?