Dr. J. Michael McGinnis is an executive officer and senior scholar at the National Academy of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.M. McGinnis, H.V. Fineberg, and V.J. Dzau. Advancing the Learning Health System. N Engl J Med 2021;385:1-5. R. Platt, G.E. Simon, and A.F. Hernandez. Is Learning Worth the Trouble? — Improving Health Care System Participation in Embedded Research. N Engl J Med 2021;385:5-7.