This podcast is designed to give medical students an organized approach to the physical exam finding of leukocoria, or an abnormal red reflex in children. Objectives of this podcast include reviewing anatomy of the eye, developing an approach to the examination of the red reflex, reviewing the differential diagnosis of leukocoria and discussing the management and referral process in a child with leukocoria. This podcast was developed by Dr. Chris Novak, a pediatric resident at the University of Alberta, with the help of Dr. Melanie Lewis, a general pediatrician and Professor at the University of Alberta and Dr. Natashka Pollock, a pediatric ophthalmologist at the Stollery Children’s Hospital in Edmonton, Alberta.