MHC Class-I Loss and Cancer Immune Escape
()
Currently unavailable
Currently unavailable
About this ebook
This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”.
Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism.
Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast…ect. as well as melanoma and lymphoma.
This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in “Tumor Immunology”.
Related to MHC Class-I Loss and Cancer Immune Escape
Titles in the series (7)
Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy Rating: 0 out of 5 stars0 ratingsImpacts of Medications on Male Fertility Rating: 0 out of 5 stars0 ratingsPericyte Biology - Novel Concepts Rating: 0 out of 5 stars0 ratingsDepressive Disorders: Mechanisms, Measurement and Management Rating: 0 out of 5 stars0 ratingsTranslational Research in Breast Cancer Rating: 0 out of 5 stars0 ratingsCo-signal Molecules in T Cell Activation: Immune Regulation in Health and Disease Rating: 0 out of 5 stars0 ratingsPhysical Virology: Virus Structure and Mechanics Rating: 0 out of 5 stars0 ratings
Related ebooks
Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach Rating: 0 out of 5 stars0 ratingsCrossing the Valley of Death with Advanced Cancer Therapy Rating: 0 out of 5 stars0 ratingsA Practical Guide to Human Cancer Genetics Rating: 5 out of 5 stars5/5Chimerism: A Clinical Guide Rating: 0 out of 5 stars0 ratingsObstetric Catastrophes: A Clinical Guide Rating: 0 out of 5 stars0 ratingsAcute Promyelocytic Leukemia: A Clinical Guide Rating: 0 out of 5 stars0 ratingsFollicular Lymphoma: Current Management and Novel Approaches Rating: 0 out of 5 stars0 ratingsThe Mediastinal Mass: A Multidisciplinary Approach Rating: 0 out of 5 stars0 ratingsHepatocellular Carcinoma: Translational Precision Medicine Approaches Rating: 0 out of 5 stars0 ratingsHistopathology of the Salivary Glands Rating: 0 out of 5 stars0 ratingsHistopathology Reporting: Guidelines for Surgical Cancer Rating: 0 out of 5 stars0 ratingsMolecular Diagnostics in Cytopathology: A Practical Handbook for the Practicing Pathologist Rating: 0 out of 5 stars0 ratingsPDQ Epidemiology Rating: 0 out of 5 stars0 ratingsPrecision Medicine in Cancer Therapy Rating: 0 out of 5 stars0 ratingsNonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine Rating: 0 out of 5 stars0 ratingsThe International System for Serous Fluid Cytopathology Rating: 0 out of 5 stars0 ratingsNeuro-Urology Rating: 0 out of 5 stars0 ratingsDiagnostic Molecular Pathology in Practice: A Case-Based Approach Rating: 0 out of 5 stars0 ratingsPhase I Oncology Drug Development Rating: 0 out of 5 stars0 ratingsMastocytosis: A Comprehensive Guide Rating: 0 out of 5 stars0 ratingsCentral Nervous System Metastases Rating: 0 out of 5 stars0 ratingsCancer on Trial: Oncology as a New Style of Practice Rating: 0 out of 5 stars0 ratingsGenomic Medicine: A Practical Guide Rating: 0 out of 5 stars0 ratingsUpper Tract Urothelial Carcinoma Rating: 0 out of 5 stars0 ratingsAtlas of Uterine Pathology Rating: 0 out of 5 stars0 ratingsTargeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment Rating: 0 out of 5 stars0 ratingsClinically Relevant Mycoses: A Practical Approach Rating: 0 out of 5 stars0 ratingsNew and Emerging Entities in Dermatology and Dermatopathology Rating: 0 out of 5 stars0 ratingsCancer Immunology: Bench to Bedside Immunotherapy of Cancers Rating: 0 out of 5 stars0 ratingsCancer Immunotherapy Meets Oncology: In Honor of Christoph Huber Rating: 0 out of 5 stars0 ratings
Medical For You
The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Rating: 5 out of 5 stars5/5The Lost Book of Simple Herbal Remedies: Discover over 100 herbal Medicine for all kinds of Ailment Inspired By Barbara O'Neill Rating: 0 out of 5 stars0 ratingsMediterranean Diet Meal Prep Cookbook: Easy And Healthy Recipes You Can Meal Prep For The Week Rating: 5 out of 5 stars5/5What Happened to You?: Conversations on Trauma, Resilience, and Healing Rating: 4 out of 5 stars4/5Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies Rating: 4 out of 5 stars4/5The Hormone Reset Diet: Heal Your Metabolism to Lose Up to 15 Pounds in 21 Days Rating: 4 out of 5 stars4/5The 40 Day Dopamine Fast Rating: 4 out of 5 stars4/5Period Power: Harness Your Hormones and Get Your Cycle Working For You Rating: 4 out of 5 stars4/5Rewire Your Brain: Think Your Way to a Better Life Rating: 4 out of 5 stars4/5Adult ADHD: How to Succeed as a Hunter in a Farmer's World Rating: 4 out of 5 stars4/5The Amazing Liver and Gallbladder Flush Rating: 5 out of 5 stars5/5The Art of Dying Well: A Practical Guide to a Good End of Life Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5Tight Hip Twisted Core: The Key To Unresolved Pain Rating: 4 out of 5 stars4/5Herbal Healing for Women Rating: 4 out of 5 stars4/5Working Stiff: Two Years, 262 Bodies, and the Making of a Medical Examiner Rating: 4 out of 5 stars4/5Healthy Gut, Healthy You: The Personalized Plan to Transform Your Health from the Inside Out Rating: 4 out of 5 stars4/5The Song of the Cell: An Exploration of Medicine and the New Human Rating: 4 out of 5 stars4/5Women With Attention Deficit Disorder: Embrace Your Differences and Transform Your Life Rating: 5 out of 5 stars5/5ATOMIC HABITS:: How to Disagree With Your Brain so You Can Break Bad Habits and End Negative Thinking Rating: 5 out of 5 stars5/5Summary of Dr. Gundry's Diet Evolution: Turn off the Genes That Are Killing You and Your Waistline Rating: 3 out of 5 stars3/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5Hidden Lives: True Stories from People Who Live with Mental Illness Rating: 4 out of 5 stars4/5
Reviews for MHC Class-I Loss and Cancer Immune Escape
0 ratings0 reviews