Atlas of Lymph Node Anatomy
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About this ebook
This book is a comprehensive atlas on lymph node anatomy and drainage to aid in cancer staging and therapy. Nodal drainage is pertinent to all aspects of cancer staging and therapy and is used by radiation oncologists, surgeons, and medical oncologists to increase accuracy. The first edition of this text was the first comprehensive monograph on this topic, allowing physicians across various specialties to utilize this information and easily share that knowledge with residents, fellows, and junior faculty.
Detailed anatomic drawings and state-of-the-art radiologic images combine to produce this essential Atlas of Lymph Node Anatomy. Utilizing the most recent advances in medical imaging, this book illustrates the nodal drainage stations in the head and neck, chest, abdomen, and pelvis. Also featured are clinical cases depicting drainage pathways for common malignancies. 2-D and 3-D maps offer color-coordinated representations of the lymph nodes in correlation with the anatomic illustrations. This simple, straightforward approach makes this book a perfect daily resource for a wide spectrum of specialties and physicians at all levels who are looking to gain a better understanding of lymph node anatomy and drainage.
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Atlas of Lymph Node Anatomy - Mukesh G. Harisinghani
© Springer Nature Switzerland AG 2021
M. G. Harisinghani (ed.)Atlas of Lymph Node Anatomyhttps://doi.org/10.1007/978-3-030-80899-0_1
1. Head and Neck Lymph Node Anatomy
Ann T. Foran¹ and Mukesh G. Harisinghani²
(1)
Department of Radiology, Beaumont Hospital, Dublin, Ireland
(2)
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Ann T. Foran
Email: foranat@tcd.ie
Mukesh G. Harisinghani (Corresponding author)
Email: mharisinghani@mgh.harvard.edu
Keywords
Papillary thyroid carcinomaSpinal accessory nerveRetropharyngeal nodeAnterior nasal cavityLevel versus node
Cancers of the head and neck—including cancers of the buccal cavity, head and neck subset, larynx, pharynx, thyroid, salivary glands, and nose/nasal passages—account for approximately 6% of all malignancies in the United States and accounted for approximately 3% of new malignancy cases in 2020 [1]. Careful analysis of nodes in the neck and knowledge of the various compartments are critical in the assessment and staging of primary head and neck malignancies. Regardless of the site of the primary tumor, the presence of a single metastatic lymph node in either the ipsilateral or the contralateral side of the neck reduces the 5-year survival rate by about 50%. The risk of cervical metastasis depends on the site of origin of the primary tumor [2].
1.1 Classification
The classification of cervical lymph nodes is complicated by the use of several different systems and the rather loose intermixing of specific names for a particular node from one system to another [3]. Of the approximately 800 lymph nodes in the body, about 300 are located in the neck. Thus, between one-fifth and one-sixth of all the nodes in the body are located in either side of the neck, making development of a classification system very complex [4].
For nearly four decades, the most commonly used classification for the cervical lymph nodes was that developed by Rouvière in 1938 who described the collar
(including occipital, mastoid, parotid, facial, retropharyngeal, submaxillary, submental, and sublingual nodes), anterior, and lateral cervical groups. The direction of nodal classification changed from that of a pure anatomic study to a nodal mapping guide for selecting the most appropriate surgical procedure among the various types of neck dissections [5].
In 1981, Shah et al. [6] suggested that the anatomically based terminology be replaced with a simpler classification based on levels. Since then, a number of classifications have been proposed that use such level, region, or zone terminology. In the past few decades, the simple level-wise classification (see Tables 1.1 and 1.2; Figs. 1.1 and 1.2) has been in use widely [7]. This system of division of neck nodes was supported by American Head and Neck Society and neck classification project [2]. However, it did not recommend adding additional levels and stated that the nodes involving regions outside the VI levels should be referred to by the name of their specific nodal group (e.g., retropharyngeal/periparotid nodes).
The ad hoc committee of the neck classification project introduced the concept of sublevels in the neck nodes, as the nodes in a particular zone in a level had different risk of metastatic involvement compared to the other zones in the same level [2].
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig1_HTML.pngFig. 1.1
(a) Important anatomical landmarks in the neck dividing the region into nodal levels. (b) Individual nodal groups are depicted (refer to color scheme)
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig2_HTML.jpgFig. 1.2
Level IB submandibular (left) and level IA submental group of nodes (right)
Table 1.1
Numeric classification system of cervical nodes
Table 1.2
Levels and sublevels of cervical lymph nodes with their anatomical boundaries
1.2 Criteria for Enlargement
The size criteria for the cervical lymph nodes has been proposed as short axis diameter greater than 11 mm in jugulodigastric and greater than 10 mm in all other cervical nodes [8]. At the time of this writing, the criteria to define cervical lymphadenopathy are (1) a discrete mass greater than 1.0–1.5 cm; (2) an ill-defined mass in a lymph node area; (3) multiple nodes of 6–15 mm; and (4) obliteration of tissue planes around vessels in a nonirradiated neck. A nodal mass with central low density is specifically indicative of tumor necrosis [7, 9–11].
1.2.1 Level I: Submental (IA) and Submandibular (IB)
1.2.1.1 Metastatic Involvement
These nodes contain metastatic disease when the primary site is lip, buccal mucosa, anterior nasal cavity, and soft tissue of cheek (see Table 1.3; Figs. 1.3 and 1.4). It is important to distinguish between level IA and IB, as IA is likely to contain metastatic disease associated with floor of mouth, lower lip, ventral tongue, and anterior nasal cavity tumors [12], whereas lesions from oral cavity subsite are likely to spread to level IB, II, and III. In the 1990 study by Candela et al. [13], level I metastases were frequent in oral cavity tumors, with a mean prevalence of 30.1%. The corresponding figure for oropharyngeal cancer was 10.3% largely because of the high prevalence in N+ disease [13].
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig3_HTML.jpgFig. 1.3
(a) Sagittal CECT scans showing an enlarged level IA (submental) node in this patient with lymphoma. The node is outlined in (b)
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig4_HTML.jpgFig. 1.4
(a) Coronal CECT scans showing an enlarged Level IB (submandibular) node in this patient with lymphoma. The node is outlined in (b)
Table 1.3
Summary of cervical lymph node involvement in various primaries
1.2.1.2 Unusual Site of Metastasis
They do not form part of the primary drainage pathway of nasopharyngeal carcinomas but may be the sole site of tumor recurrence after radiotherapy. This is thought to be due to fibrosis of the lymphatic vessels in the irradiated regions resulting in diversion of lymph drainage to the submental nodes [14].
1.2.2 Level II
Internal jugular chain lymph nodes (see Fig. 1.5) are frequently divided into IIA (see Fig. 1.6) and IIB by spinal accessory nerve [2]. As the nerve cannot be identified on the CT scan, the Brussels guidelines used a criteria from radiological point of view proposed by Som et al. [15], which takes the posterior edge of the internal jugular vein (IJV) for subdivisions between levels IIA and IIB (see Figs. 1.7 and 1.8).
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig5_HTML.jpgFig. 1.5
Internal jugular chain of lymph nodes (level II). These nodes can be further divided into IIA and IIB by spinal accessory nerve. The red color represents branches of external carotid artery
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig6_HTML.pngFig. 1.6
(a) Axial CECT showing enlarged IIA level nodes. Note central hypodensity in these nodes which represent necrosis. The node is outlined in (b)
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig7_HTML.pngFig. 1.7
(a) Axial CECT showing enlarged level II nodes. These are further divided into IIA and IIB based on the posterior edge of internal jugular vein. The nodes are outlined in (b)
../images/217552_2_En_1_Chapter/217552_2_En_1_Fig8_HTML.pngFig. 1.8
(a) Axial CECT showing single level IIA and multiple level IIB nodes. The nodes are outlined in (b)
1.2.2.1 Metastatic Involvement
Level