Laser Management of Scars
()
About this ebook
This book addresses the management of scars using lasers and light. The authors provide a comprehensive overview of the current laser modalities and the science and evidence behind them. They also present various treatments, including those using carbon dioxide lasers, Erbium:YAG lasers, pulsed dye lasers and Q-switched lasers. The book includes detailed information on the treatment of burn, acne, keloid and hypertrophic scars, as well as discussions of the complications of laser treatments and ethical and medico-legal issues.
Scars have many causes, including trauma and burns, but also medical treatments themselves - scars are an inevitable consequence of most surgery. There have been significant advances in laser and light technology over the last decade, and the management of scars with a variety of lasers has been adopted both in traditional healthcare settings and in the cosmetic sector. Edited by a respected burns and plastic surgeon, this book is a valuable resource for a variety of clinicians including dermatologists, laser practitioners, physiotherapists and occupational therapists, burn care professionals, as well as multidisciplinary teams working with patients with scars of all aetiologies.
Related to Laser Management of Scars
Related ebooks
Customized Laser Vision Correction Rating: 0 out of 5 stars0 ratingsAtlas of Lasers and Lights in Dermatology Rating: 0 out of 5 stars0 ratingsCataract Surgery: Pearls and Techniques Rating: 0 out of 5 stars0 ratingsTextbook of Refractive Laser Assisted Cataract Surgery (ReLACS) Rating: 0 out of 5 stars0 ratingsAdvances in Periodontal Surgery: A Clinical Guide to Techniques and Interdisciplinary Approaches Rating: 0 out of 5 stars0 ratingsLasers in Oral and Maxillofacial Surgery Rating: 0 out of 5 stars0 ratingsPlatelet-Rich Plasma in Dermatologic Practice Rating: 0 out of 5 stars0 ratingsA DXA Primer for the Practicing Clinician: A Case-Based Manual for Understanding and Interpreting Bone Densitometry Rating: 0 out of 5 stars0 ratingsGuided Endodontics Rating: 0 out of 5 stars0 ratingsAdvanced Techniques in Minimally Invasive and Robotic Colorectal Surgery Rating: 0 out of 5 stars0 ratingsUltrasound-Assisted Liposuction: Current Concepts and Techniques Rating: 0 out of 5 stars0 ratingsFemtosecond Laser - Principles and Application in Ophthalmology Rating: 0 out of 5 stars0 ratingsEndodontic Radiology Rating: 0 out of 5 stars0 ratingsCutting-edge Vitreoretinal Surgery Rating: 0 out of 5 stars0 ratingsAdvances in Ocular Imaging in Glaucoma Rating: 0 out of 5 stars0 ratingsImage Guided Dermatologic Treatments Rating: 0 out of 5 stars0 ratingsBiomedical Imaging: Principles and Applications Rating: 0 out of 5 stars0 ratingsCone Beam Computed Tomography: Oral and Maxillofacial Diagnosis and Applications Rating: 0 out of 5 stars0 ratingsOral and Maxillofacial Radiology: A Diagnostic Approach Rating: 5 out of 5 stars5/5Panoramic Radiology Rating: 0 out of 5 stars0 ratingsEthics of Innovation in Neurosurgery Rating: 0 out of 5 stars0 ratingsPosterior Uveitis: Advances in Imaging and Treatment Rating: 0 out of 5 stars0 ratingsCT at a Glance Rating: 0 out of 5 stars0 ratingsPractical Radiation Oncology Rating: 0 out of 5 stars0 ratingsCommon Problems in Acute Care Surgery Rating: 0 out of 5 stars0 ratingsLaser Dermatology Rating: 0 out of 5 stars0 ratingsControversies in the Management of Keratoconus Rating: 0 out of 5 stars0 ratingsAdvanced Practice and Leadership in Radiology Nursing Rating: 0 out of 5 stars0 ratingsTechnology in Practical Dermatology: Non-Invasive Imaging, Lasers and Ulcer Management Rating: 0 out of 5 stars0 ratingsSecondary Fracture Prevention: An International Perspective Rating: 0 out of 5 stars0 ratings
Medical For You
The 40 Day Dopamine Fast Rating: 4 out of 5 stars4/5Mating in Captivity: Unlocking Erotic Intelligence Rating: 4 out of 5 stars4/5Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies Rating: 4 out of 5 stars4/5The Lost Book of Simple Herbal Remedies: Discover over 100 herbal Medicine for all kinds of Ailment Inspired By Barbara O'Neill Rating: 0 out of 5 stars0 ratingsThe Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Rating: 5 out of 5 stars5/5What Happened to You?: Conversations on Trauma, Resilience, and Healing Rating: 4 out of 5 stars4/5The Hormone Reset Diet: Heal Your Metabolism to Lose Up to 15 Pounds in 21 Days Rating: 4 out of 5 stars4/5Adult ADHD: How to Succeed as a Hunter in a Farmer's World Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5Mediterranean Diet Meal Prep Cookbook: Easy And Healthy Recipes You Can Meal Prep For The Week Rating: 5 out of 5 stars5/5The White Coat Investor: A Doctor's Guide to Personal Finance and Investing Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Living Daily With Adult ADD or ADHD: 365 Tips o the Day Rating: 5 out of 5 stars5/5Lifting the Fog: A specific guide to inattentive ADHD in adults Rating: 4 out of 5 stars4/5Tight Hip Twisted Core: The Key To Unresolved Pain Rating: 4 out of 5 stars4/5Summary of Dr. Gundry's Diet Evolution: Turn off the Genes That Are Killing You and Your Waistline Rating: 3 out of 5 stars3/5ATOMIC HABITS:: How to Disagree With Your Brain so You Can Break Bad Habits and End Negative Thinking Rating: 5 out of 5 stars5/5The Gene: An Intimate History Rating: 4 out of 5 stars4/5Herbal Healing for Women Rating: 4 out of 5 stars4/5The Amazing Liver and Gallbladder Flush Rating: 5 out of 5 stars5/5David D. Burns’ Feeling Good: The New Mood Therapy | Summary Rating: 4 out of 5 stars4/5The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5Women With Attention Deficit Disorder: Embrace Your Differences and Transform Your Life Rating: 5 out of 5 stars5/5Hidden Lives: True Stories from People Who Live with Mental Illness Rating: 4 out of 5 stars4/5
Reviews for Laser Management of Scars
0 ratings0 reviews
Book preview
Laser Management of Scars - Kayvan Shokrollahi
© Springer Nature Switzerland AG 2020
K. Shokrollahi (ed.)Laser Management of Scarshttps://doi.org/10.1007/978-3-030-52919-2_1
Introduction to Lasers and Their Use in Scar Management
Kayvan Shokrollahi¹
(1)
Burns and Plastic Surgery Unit, Whiston Hospital, Liverpool, UK
Keywords
LaserScarIntroduction
1 Principles of Laser–Tissue Interactions
Laser light, when delivered into tissue, interacts in a number of different ways. These specific interactions depend on the tissue type, wavelength of the laser as well as the laser energy delivered into the tissues (fluence). A laser beam will continue to travel through tissue until it is absorbed, and the specific entity within the skin that absorbs that energy is known as the chromophore. Three main chromophores of therapeutic relevance reside in the skin:
Haemoglobin (blood)
Melanin (skin pigment)
Water
Vascular lasers are absorbed well by haemoglobin and exert their therapeutic effects through this absorption. Hence, a vascular scar or area of telangiectasia will absorb laser energy and (for instance) result in coagulation or disruption of fine vessels.
Lasers that target melanin are useful for depilation, and in some circumstances for treatment of pigmentation.
Lasers that target water are typically ablative lasers which cause a degree of tissue destruction, acting superficially at first and penetrating deeper dependant on the power of the laser used, the pulse duration, and the method and duration of delivery. Lasers such as the CO2 laser can be deployed either as a single beam or as various larger patterns through use of a computer pattern generator (CPG) that can not only treat larger areas in one go but also ‘fractionate’ the delivery of the laser energy to spare selected densities of tissue to allow for more rapid and consistent healing with reduced ‘downtime’ and with reduced risk.
With the appropriate selection of laser (wavelength), fluence (energy and density) and pulse duration, and other factors, selective destruction of a specific target becomes possible—termed selective photothermolysis. The depth of the skin penetration, from epidermis down to subcutaneous tissue, varies depending on the wavelength of laser light, spot size, amount of chromophore, and various other factors.
2 Scar Characteristics Commonly Amenable to Laser Therapy
Erythema
Dyschromia, hyperpigmentation, and hypopigmentation
Atrophy
Telangiectasia
Contour
Pliability
Scar folliculitis
Iatrogenic, e.g. ‘post-corticosteroid’, post-meshed skin grafts, and heterotopic hair.
3 Providing a Laser Scar Service
Most scars have more than one treatable problem, e.g. erythema + pigmentation + texture and patients themselves have different skin types (I to VI). These different scars in different patients require different lasers and different strategies to deal with all the variables. It is simply not possible to have a ‘one-laser’ approach to all scars, and indeed such a strategy can lead to poor results or itself cause complications or scarring. Therefore, a comprehensive suite of lasers is typically required including:
Vascular lasers
Ideally long-pulsed pulsed dye and/or Nd:YAG lasers
Depilatory lasers
Such as Alexandrite, diode, and Nd:YAG (for type 5 or 6 skin)
Ablative lasers
Primarily carbon dioxide lasers, but also erbium:YAG. These should be able to deliver ablative and fractionated delivery.
Patient expectations will need to be managed appropriately, and laser will typically fit into a treatment regime encompassing multiple different modalities such as:
Corticosteroid injections or other topical drug interventions
Cosmetic camouflage
Pressure garments (burns)
Topical silicone
Massage (physical or mechanical)
Surgery, dermabrasion, needling
Patients with scars are ideally managed in the context of a scar MDT with multiple modalities on offer including laser and with access to counselling and mental health support.
Laser are not a panacea and there must be appropriate expectations from clinicians and patients alike. The one thing that patients want from scar treatments is the thing they cannot have: the ‘removal’ of their scars. A holistic approach including camouflage, ancillary treatments, and psychological input as needed are essential.
Clinicians have yet to develop the objective and patient-reported measures needed to evaluate laser treatments in the areas where it can make the most difference—for example the ability of patients to cover their scars with camouflage or makeup. Simultaneous with the development and expansion of light-based interventions for scar management, we also need to come out of the dark when it comes to the development of objective measures, subjective measures, patient-reported measures, and aspects such as camouflagability of scarring. There are huge challenges in this area because every scar and injury is different, every patient is different and has a different skin type, the anatomical location of scars are different, the mechanisms of injury and depths are different, and the co-morbidities are different. When combined with the essential requirement for many patients to have, for clinical reasons, multimodal treatments, this presents potentially insurmountable challenges in this area.
We must both recognise these challenges and strive to capture the best evidence. We must be cognisant that the world evidence in this domain is mostly based in level 4 and 5 evidence and case series.
Further Reading
Lindsay KJ, Shokrollahi K. Laser management of scars (chap. 44). In: Whitaker IS, Shokrollahi K, Dickson WA, editors. Burns (OSH surgery). Oxford: Oxford University Press; 2019. ISBN-13: 9780199699537. https://doi.org/10.1093/med/9780199699537.001.0001.Crossref
© Springer Nature Switzerland AG 2020
K. Shokrollahi (ed.)Laser Management of Scarshttps://doi.org/10.1007/978-3-030-52919-2_2
Pathophysiology of Scarring
Nastaran Sargazi¹, David Bodansky¹ and Kayvan Shokrollahi²
(1)
Mersey Regional Burns and Plastic Surgery Unit, St Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, Merseyside, UK
(2)
Burns and Plastic Surgery Unit, Whiston Hospital, Liverpool, UK
Keywords
ScarPathophysiologyModulationSkin
1 Wound Healing and Scarring
When cutaneous integrity is disrupted, wound healing and the formation of scars are essential in providing a protective barrier against infection and fluid loss [1]. Wound healing is a complex process triggered by an initial insult, which progresses in a systematic manner and is categorised into three specific phases: inflammatory, proliferative and remodelling [2]. The duration of this cascade of events varies between individuals and can take many months to complete [2].
Within minutes of the initial insult, clot formation at the wound site initiates the inflammatory phase [2] by attracting inflammatory cells, in particular neutrophils, which migrate to the area of trauma [3]. Neutrophil-specific enzymes, including collagenases, are hypothesised to contribute to scar formation by resulting in areas of excessive tissue loss, thereby leaving large defects which are ultimately replaced during the remodelling phase by scar tissue [4]. Chemotactic agents also result in migration of monocytes to the region of injury which are transformed into macrophages on reaching the wound site and not only act in an inflammatory manner but also play a vital role in the proliferative phase by stimulating angiogenesis and re-epithelialisation [5].
The proliferative phase ensues over the next few days to weeks and consists of a chain of events resulting in repair of both the dermal and epidermal layers [3]. This stage involves a range of processes including angiogenesis, granulation tissue formation, deposition of collagen, re-epithelialization and retraction of the wound which ultimately results in scar formation [6]. In the process of angiogenesis, a rich network of capillaries created from surrounding healthy blood vessels are formed throughout the wound [6]. These are initially fragile and relatively permeable, resulting in a degree of tissue oedema [6].
Next, collagen deposition occurs as a result of secretion of extracellular matrix proteins by fibroblasts following their migration and proliferation in the wound [6].The resulting vascularised, pink fibrous tissue is termed granulation tissue and acts to replace the clot previously formed at the site of trauma [6]. Once adequate quantities of matrix are laid down, fibroblasts differentiate into myofibroblasts and initiate wound contraction [6]. Re-epithelialisation occurs early in this process, with keratinocytes migrating from wound edges to cover the granulation tissue and proliferating across the denuded area of skin [5], thereby differentiating into a new layer of epidermis [3]. In its final stage, the wound enters the maturation phase during which the granulation tissue undergoes remodelling by its constituent cells, thereby allowing organisation of the scar [3].
Scar formation is the normal physiological response to cutaneous trauma [7]; however, the complex interaction that occurs between the numerous cells and their inflammatory mediators during the process of healing does not necessarily result in the formation of smooth and normal skin [8]. Dysregulation, in particular stages of the healing process, results in abnormal collagen deposition, hence, leading to excessive scar formation [9], thereby resulting in a spectrum of scar types [10], of which three are particularly amenable to laser treatment: atrophic scars, hypertrophic scars and keloids [11].
1.1 Hypertrophic Scars
Hypertrophic scars occur following an exaggerated proliferative response to wound healing [12], which results in excess collagen deposition [13]that by definition characteristically remain within the boundaries of the original wound [12]. Clinically, they appear as raised, itchy, erythematous, nodular lesions which are frequently found in areas of thicker skin [12]. They are normally present within 1 month of the initial injury, regress with time and are categorised into two types: linear and widespread [13].
The linear subtype is a rope-like lesion which usually occurs following direct trauma or surgery whilst the widespread subtype is found following burns, extensive cutaneous trauma or infection [13]. Histologically, hypertrophic scars consist of disorganised arrangement of collagen assembled in a whorl-like pattern instead of the usual parallel orientation found in normal skin, giving it its characteristic raised appearance [12].Current literature shows a great range in the incidence of hypertrophic scars, with estimated rates of 30–91% following burns and 40–94% following surgery [14]. This large variation in rates has been attributed to inconsistencies in its correct identification [14].
1.2 Keloid Scars
In contrast to hypertrophic scars, keloid scars are characteristically more extensive and by definition extend beyond the margins of the wound, therefore invade normal adjacent skin [15]. Like hypertrophic scars, they are benign hyperproliferative growths developing from dense fibrous tissue following abnormal wound healing [12]. Histologically, they consist of nodules of thickened collagen bundles with relatively few fibroblasts [16], which pathognomonically invade the normal dermal layer of skin, thereby resulting in a subcutaneous mass [17]. Clinically, this results in a characteristic raised, pruritic and often painful scar which extends beyond the wound margins [18]. They can be differentiated into minor or major keloids, with the latter being larger (>0.5 cm) and more pronounced [18]. Despite their unclear aetiology, keloids tend to occur within 12 months of localised trauma, which can be in the form of surgery, tattoos, lacerations, bites, vaccinations or blunt trauma [19] and generally fail to regress with time [16].
Both hypertrophic scars and keloids form in all races; however, there is a greater predisposition in individuals with darker skin and those with greater pigment production [19]. In addition, other variables including genetic factors, hormonal levels and age play a role in the formation of such lesion [14], with most keloids occurring between the age of 10 and 30 years [19]. Furthermore, both these scars have a propensity to develop in areas exhibiting high tension [20] and slow wound healing in addition to movement- and pressure-dependent areas [13], with keloids commonly found over the earlobes, upper arm, upper back and the anterior chest, in particular the pre-sternal area [16].
The clinical distinction between keloid and hypertrophic scars is of great importance in establishing the correct management plan, in particular when deciding on the mode of laser management [16]. In general, whilst both scars tend to result from a similar pathological process, the main distinguishing features are the extension of the scar beyond the wound margin and failure to regress over time which is seen with keloids alone [20]. Further distinguishing features are described in more detail in Table 1.
Table 1
Features of hypertrophic vs. keloid scars [7]
1.3 Atrophic Scars
Atrophic scars are a well-documented complication of acne [21], resulting from inflammatory changes which lead to dermal fat and collagen loss [22]. Clinically, they are present as broad, oval-like dermal depressions, which classically peaks in incidence during late teens to early adulthood [23]. Histologically, the loss of dermal collagen and fat results in downward displacement of the epidermis, thereby resulting in these characteristic lesions [23].These generally tend to worsen with time due to increased laxity of the skin with age [22].
In addition to the clinical impact of the scars described above, such defects can be disfiguring and hence lead to significant cosmetic concerns by patients, therefore result in considerable emotional, physical and psychological distress [10]. Consequently, a great deal of research has been undertaken within this field in order to minimise the impact of such lesions and avoid further progression [10]. Whilst a range of medical and topical agents are available for the management of such scars, this book focuses on the various laser modalities available and their place within the overall scar management pathway.
References
1.
Van der Veer WM, Bloemen MCT, Ulrich MMW, Molema G, van PPM Z, Middelkoop E, et al. Potential cellular and molecular causes of hypertrophic scar formation. Burns. 2009;35(1):15–29.Crossref
2.
Butler PD, Longaker MT, Yang GP. Current progress in keloid research and treatment. J Am Coll Surg. 2008;206(4):731–41.Crossref
3.
Rhett JM, Ghatnekar GS, Palatinus JA, Q’Quinn M, Yost MJ, Gourdie RG. Novel therapies for scar reduction and regenerative healing of skin wounds. Trends Biotechnol. 2008;26:173–80.Crossref
4.
Reish RG, Eriksson E. Scar treatments: preclinical and clinical studies. J Coll Surg. 2008;206:719–30.Crossref
5.
Waibel JS, Rudnick A. Current trends and future considerations in scar treatment. Semin Cutan Med Surg J. 2015;34:13–6.Crossref
6.
Young A, McNaught C. The physiology of wound healing. Surgery. 2011;29:10.
7.
Arno AI, Gauglitz GG, Barret JP, Jeschke MG. Up-to-date approach to manage keloids and hypertrophic scars: a useful guide. Burns. 2014;40:1255–66.Crossref
8.
Alster TS, West TB. Treatment of scars: a review. Ann Plast Surg. 1997;39:418–32.Crossref
9.
Enoch S, Leaper DJ. Basic science of wound healing. Surgery. 2008;26:31–7.
10.
Monstrey S, Middelkoop E, Vranckx JJ, Bassetto F, Ziegler UE, Meaume S, Téot L. Updated scar management practical guidelines: non-invasive and invasive measures. J Plast Reconstruct Aesthet Surg. 2014;67:1017–25.Crossref
11.
Elsaie ML, Choudhary S, McLeod M, Nouri K. Scars. Curr Prob Dermatol. 2011;42:131–9.Crossref
12.
Zurada JM, Kriegel D, Davis IC. Topical treatments for hypertrophic scars. J Am Acad Dermatol. 2006;55:1024–31.Crossref
13.
Khatri KA, Mahoney DL, McCartney MJ. Laser scar revision: a review. J Cosmet Laser Ther. 2011;13:54–62.Crossref
14.
Bloemen MC, van der Veer WM, Ulrich MM, van Zuijlen PP, Niessen FB, Middelkoop E. Prevention and curative management of hypertrophic scar formation. Burns. 2009;35:463–75.Crossref
15.
Robles DT, Berg D. Abnormal wound healing: keloids. Clin Dermatol. 2007;25:26–32.Crossref
16.
Lee JY, Yang CC, Chao SC, Wong TW. Histopathological differential diagnosis of keloid and hypertrophic Scar. Am J Dermatopathol. 2004;26:379–84.Crossref
17.
Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstruct Aesthet Surg. 2008;61:4–17.Crossref
18.
Murray JC, Pollack SV, Pinnell SR. Keloids: a review. J Am Acad Dermatol. 1984;4:4.
19.
Murray JC. Keloids and hypertrophic scars. Clin Dermatol. 1994;12:27–37.Crossref
20.
Mafong EA, Ashinoff R. Treatment of hypertrophic scars and keloids: a review. Aesthet Surg J. 2000;20:2.Crossref
21.
Woo SH, Park JH, Kye YC. Resurfacing of different types of facial acne scar with short-pulsed, variable-pulsed, and dual-mode Er:YAG laser. Dermatol Surg. 2004;30:488–93.PubMed
22.
O’Daniel TG. Multimodal management of atrophic acne scarring in the aging face. Aesthetic Plast Surg. 2011;35:1143–50.Crossref
23.
Jordan R, Cummins C, Buris A. Laser resurfacing of the skin for the improvement of facial acne scarring: a systematic review of the evidence. Br J Dermatol. 2000;142:413–23.Crossref
© Springer Nature Switzerland AG 2020
K. Shokrollahi (ed.)Laser Management of Scarshttps://doi.org/10.1007/978-3-030-52919-2_3
Decision-Making for Safe and Effective Laser Treatment: The Laser Test Patch
Kayvan Shokrollahi¹ and Charlotte Defty²
(1)
Burns and Plastic Surgery Unit, Whiston Hospital, Liverpool, UK
(2)
Mersey Regional Centre for Burns and Plastic Surgery, Whiston Hospital, Liverpool, UK
Keywords
Test patchingPatch testSkin testLaserNegligence
1 Introduction
Laser test patching is a fundamental step in performing a laser treatment and its importance should not be overlooked. It is a frequent key in achieving the optimal result whilst avoiding complications. A test patch is carried out to help select the most effective, safe treatment as smoothly as possible, whilst avoiding overtreating and the resultant adverse effects. Patient satisfaction with the treatment process and outcome is paramount and this is neither accomplished by undertreating patients and having no side effects nor by successfully treating the presenting complaint but leaving unnecessary scarring, pigment alteration and other problems. Test patching also demonstrates that steps were taken to avoid complications and can play an important role in supporting the clinician’s practice if adverse effects were to arise. There are however circumstances when a test patch is neither practical nor beneficial.
2 General Principles of Performing a Test Patch [1]
A test patch should be performed in most laser treatments to help select the most effective laser settings for the condition and site being treated according to Shokrollahi’s principles [1]. The aim of test patching is to define parameters which are maximally effective, safe and have minimal adverse effects, following which full treatments can be performed with confidence. Decisions regarding the parameters for the test patch are based on the underlying condition, the skin type of the patient, the anatomical site and the laser being used [2]. A range of parameters usually within the manufacturer’s recommendations should be tried. Straying beyond manufacturers parameters is not a problem in itself and can often be required to get the desired