Evaluation and Management of Autonomic Disorders: A Case-Based Practical Guide
()
About this ebook
Related to Evaluation and Management of Autonomic Disorders
Related ebooks
Neuropathology Simplified: A Guide for Clinicians and Neuroscientists Rating: 0 out of 5 stars0 ratingsBeyond The Brain Re-Thinking Epilepsy Diagnosis And Treatment Through The Mind-Body Connection Rating: 0 out of 5 stars0 ratingsNeuromodulation in Headache and Facial Pain Management: Principles, Rationale and Clinical Data Rating: 0 out of 5 stars0 ratingsNeurometabolic Hereditary Diseases of Adults Rating: 0 out of 5 stars0 ratingsApproach To Neuropsychology Rating: 0 out of 5 stars0 ratingsPeripheral Interventional Management in Headache Rating: 0 out of 5 stars0 ratingsGale Researcher Guide for: Organic Illness and Psychiatry Rating: 0 out of 5 stars0 ratingsClinical Systems Neuroscience Rating: 0 out of 5 stars0 ratingsNeurophysiology of the Migraine Brain Rating: 0 out of 5 stars0 ratingsDecoding the Brain: A Guide to Understanding Functional Neurological Disorder Rating: 0 out of 5 stars0 ratingsClinical Psychopharmacology for Neurologists: A Practical Guide Rating: 0 out of 5 stars0 ratingsGale Researcher Guide for: Overview of Physiology and Neuropsychology Rating: 0 out of 5 stars0 ratingsSystems Neuroscience in Depression Rating: 0 out of 5 stars0 ratingsBrain Injury Specialist - The Comprehensive Guide: Vanguard Professionals Rating: 0 out of 5 stars0 ratingsUnderstanding Brain Tumors: A Simplified Guide Rating: 0 out of 5 stars0 ratingsPsychopharmacology: A Clinician's Guide for the Effective use of Psychotropic Medications Rating: 0 out of 5 stars0 ratingsIntegrative Headache Medicine: An Evidence-Based Guide for Clinicians Rating: 0 out of 5 stars0 ratingsBrain Sciences in Psychiatry Rating: 0 out of 5 stars0 ratingsThe Molecular and Clinical Pathology of Neurodegenerative Disease Rating: 0 out of 5 stars0 ratingsThe Neurologic Diagnosis: A Practical Bedside Approach Rating: 0 out of 5 stars0 ratingsNon Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences Rating: 0 out of 5 stars0 ratingsAcquired Brain Injury: An Integrative Neuro-Rehabilitation Approach Rating: 0 out of 5 stars0 ratingsNeuropsychiatric Guide to Modern Everyday Psychiat Rating: 0 out of 5 stars0 ratingsSleep and Neurologic Disease Rating: 0 out of 5 stars0 ratingsNervous System: A Tutorial Study Guide Rating: 5 out of 5 stars5/5The Little Black Book of Neuropsychology: A Syndrome-Based Approach Rating: 5 out of 5 stars5/5Comprehensive Understanding of the Vagus Nerve Rating: 0 out of 5 stars0 ratingsSleep Neurology: A Comprehensive Guide to Basic and Clinical Aspects Rating: 0 out of 5 stars0 ratingsDigital Neuroanatomy Rating: 0 out of 5 stars0 ratings
Medical For You
Women With Attention Deficit Disorder: Embrace Your Differences and Transform Your Life Rating: 5 out of 5 stars5/5The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Rating: 5 out of 5 stars5/5What Happened to You?: Conversations on Trauma, Resilience, and Healing Rating: 4 out of 5 stars4/5Brain on Fire: My Month of Madness Rating: 4 out of 5 stars4/5Mediterranean Diet Meal Prep Cookbook: Easy And Healthy Recipes You Can Meal Prep For The Week Rating: 5 out of 5 stars5/5The Emperor of All Maladies: A Biography of Cancer Rating: 5 out of 5 stars5/5Adult ADHD: How to Succeed as a Hunter in a Farmer's World Rating: 4 out of 5 stars4/5The People's Hospital: Hope and Peril in American Medicine Rating: 4 out of 5 stars4/5Herbal Healing for Women Rating: 4 out of 5 stars4/5The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5The Lost Book of Simple Herbal Remedies: Discover over 100 herbal Medicine for all kinds of Ailment Inspired By Barbara O'Neill Rating: 0 out of 5 stars0 ratingsThe Song of the Cell: An Exploration of Medicine and the New Human Rating: 4 out of 5 stars4/5Working Stiff: Two Years, 262 Bodies, and the Making of a Medical Examiner Rating: 4 out of 5 stars4/5ATOMIC HABITS:: How to Disagree With Your Brain so You Can Break Bad Habits and End Negative Thinking Rating: 5 out of 5 stars5/5Living Daily With Adult ADD or ADHD: 365 Tips o the Day Rating: 5 out of 5 stars5/5Tight Hip Twisted Core: The Key To Unresolved Pain Rating: 4 out of 5 stars4/5"Cause Unknown": The Epidemic of Sudden Deaths in 2021 & 2022 Rating: 5 out of 5 stars5/5The Art of Dying Well: A Practical Guide to a Good End of Life Rating: 4 out of 5 stars4/5A Letter to Liberals: Censorship and COVID: An Attack on Science and American Ideals Rating: 3 out of 5 stars3/5Hidden Lives: True Stories from People Who Live with Mental Illness Rating: 4 out of 5 stars4/5Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies Rating: 4 out of 5 stars4/5Rewire Your Brain: Think Your Way to a Better Life Rating: 4 out of 5 stars4/5The Hormone Reset Diet: Heal Your Metabolism to Lose Up to 15 Pounds in 21 Days Rating: 4 out of 5 stars4/5
Reviews for Evaluation and Management of Autonomic Disorders
0 ratings0 reviews
Book preview
Evaluation and Management of Autonomic Disorders - Juan Idiaquez
Part IGeneral Principles
© Springer International Publishing AG 2018
Juan Idiaquez, Eduardo Benarroch and Martin Nogues (eds.)Evaluation and Management of Autonomic Disordershttps://doi.org/10.1007/978-3-319-72251-1_1
1. Anatomy, Physiology, and Pharmacology of the Autonomic Nervous System (ANS)
Juan Idiaquez¹ , Eduardo Benarroch² and Martin Nogues³
(1)
Universidad de Valparaiso, Viña del Mar, Chile
(2)
Mayo Clinic, Rochester, MN, USA
(3)
Clinica Fleni, Buenos Aires, Argentina
Juan Idiaquez (Corresponding author)
Email: idiaquez@123.cl
Eduardo Benarroch
Email: benarroch@mayo.edu
Martin Nogues
Email: mnogues@fleni.org.ar
The ANS is a component of the nervous system that has a major role in the maintenance of homeostasis and adaptive responses to external or internal stressors. It innervates all organs of the body, including the eye, the skin, and the cardiovascular, respiratory, gastrointestinal, and genitourinary systems, and functionally interacts with the endocrine, pain, and motor systems. The ANS consists of three subdivisions: the sympathetic, parasympathetic, and enteric nervous systems. The sympathetic and parasympathetic systems each have a central preganglionic neuron in the brainstem or spinal cord and a peripheral neuron in the autonomic ganglia. The preganglionic neurons receive and integrate two types of information, inputs from primary visceral afferents that trigger autonomic reflexes and descending inputs from central autonomic areas that initiate responses to stress, emotion, and other behavioral states. The enteric nervous system consists of neurons located in ganglia within the walls of the gut that participate in local reflexes (Fig. 1.1).
../images/420887_1_En_1_Chapter/420887_1_En_1_Fig1_HTML.gifFigure 1.1
General organization of the autonomic nervous system
1.1 Central Autonomic Areas
Several interconnected areas of the cerebral cortex, diencephalon, and brainstem control autonomic function brain.
A.
The insular cortex is the primary visceral sensory cortex. The posterior dorsal insula receives, via the thalamus, inputs from pathways transmitting visceral as well as pain and thermal information. The anterior insula, via its interactions with other cortical areas and the amygdala, is involved in conscious awareness of the bodily sensations.
B.
The anterior cingulate cortex is the cortical autonomic motor area; it includes a rostral portion that is involved in emotional regulation and a dorsal subdivision, which initiates autonomic responses associated with cognitive control, including motivation and decision-making.
C.
The amygdala is a nuclear complex that has a critical role in emotion and social behavior. It consists of a basolateral complex that integrates information from multiple sensory modalities and is critical for acquisition and consolidation of conditioned responses (including fear) and a central nucleus that initiates autonomic, endocrine, and motor responses to emotion via its inputs to the hypothalamus and brainstem.
D.
The hypothalamus has a critical role in the generation of integrated autonomic, endocrine, and behavioral responses for maintenance of homeostasis and adaptation to internal or external stimuli. It consists of a periventricular zone that contains nuclei that control hormone secretion by the hypophysis; a lateral zone containing nuclei involved in thermoregulation, osmoregulation, and regulation of feeding, energy metabolism, and reproduction; and a lateral zone that participates in motivated behavior and regulation of the sleep-wake cycle. The main hypothalamic areas controlling autonomic function are the paraventricular nucleus, which is involved in responses to stress, and the lateral hypothalamic area, which is involved in behavioral arousal.
E.
Theperiaqueductal gray matter (PAG), located in the midbrain, integrates descending inputs from the cerebral cortex, amygdala, and hypothalamus with ascending inputs from pathways conveying pain and visceral sensation. The PAG consists of several regions that coordinate motor and cardiovascular responses to stress, are critical for central modulation of pain, and mediate the cortical control of micturition and other visceral functions.
F.
The parabrachial nucleus, located in the dorsal pons, is a critical integration center that receives visceral, nociceptive, and thermic inputs from the spinal cord and nucleus of the solitary tract and relays this information to the hypothalamus, amygdala, and thalamus. This nucleus also has an important role in control of respiration.
G.
The nucleus of the solitary tract (NTS), located in the posterior medulla, is the first relay station for visceral inputs from cardiovascular, respiratory, and gastrointestinal receptors conveyed by the glossopharyngeal and particularly the vagus nerves. This nucleus has two main functions: (1) initiation of medullary reflexes controlling blood pressure, heart rate, respiration, and gastrointestinal motility and (2) relay of visceral information to the hypothalamus and other brain areas, both directly and via projections to the parabrachial nucleus. The nucleus off the solitary tract is also the primary relay of inputs from taste receptors.
H.
The ventrolateral medulla contains several groups of neurons that are critical for cardiovascular and respiratory function. They include sympathoexcitatory vasomotor neurons of the rostral ventrolateral medulla(VLM) that project to the intermediolateral cell columns and are critical for control of blood pressure, neurons in the ventrolateral portion of the nucleus ambiguus that control the heart rate via the vagus nerve, and neurons of the ventral respiratory group extending throughout the medulla and controlling the
I.
Themedullary raphe contains different groups of neurons that participate in mechanisms of thermoregulation (responses to cold), automatic ventilation, and pain modulation.
1.2 Organization of the Sympathetic and Parasympathetic Systems
Sympathetic Nervous System
The preganglionic sympathetic neurons are located in the intermediolateral cell column and the T1 to L2 segment of the spinal cord. They are organized into different functions controlling cardiac, vasomotor, sudomotor, and visceral effectors. These preganglionic sympathetic subunits receive descending inputs from the hypothalamus and brainstem and segmental inputs from the periphery via dorsal root ganglia afferents. The preganglionic sympathetic neurons control visceral function via projections to two types of ganglia, paravertebral and prevertebral. The paravertebral ganglia form the sympathetic chain, which is like a string of beads on each side of the vertebral column, and contain the ganglion neurons that innervate the cranial effectors (including the eye and cerebral blood vessels), skin, and thoracic and abdominal, visceral including the heart, lungs, and gastrointestinal tract. The prevertebral ganglia lie anterior to the vertebral column, mostly on the abdominal aorta and its major branches, and innervate all visceral and blood vessels of the abdomen and pelvis, including the rectum, bladder, and genital organs. A third effector of the sympathetic system is the adrenal medulla, which receives inputs from the intermediolateral cell column and releases epinephrine to the general circulation.
Parasympathetic Nervous System
The preganglionic parasympathetic neurons include two groups, cranial and sacral. The cranial parasympathetic neurons occupy the general visceral efferent column of the brainstem and provide inputs from that area carried by cranial nerves to local ganglia that innervate effectors in the face, thorax, and abdomen, for example, the Edinger–Westphal nucleus projects , via the oculomotor (III) cranial nerve to the ciliary ganglion, which innervates the eye, and the superior and inferior salivatory nuclei project, via the facial (VII) and glossopharyngeal (IX) nerve to cranial blood vessels and lacrimal and salivary glands. The dorsal motor nucleus of the vagus provides the most widespread parasympathetic output and projects to ganglia located in plexus innervating the heart and respiratory system, as well as intrinsic plexus neurons of the enteric nervous system of the esophagus, stomach, small intestine, ascending, and transverse colon. Neurons in the ventrolateral portion of the nucleus ambiguus provide the vagal output to the sinus node and control of heart rate. The sacral parasympathetic neurons are located in the sacral parasympathetic nucleus at the S2–S4 levels of the sacral cord and provide inputs to the ganglia innervating the descending colon, rectum, gladder, and genital organs.
Specific Functional Circuits
Control of Blood Pressure
The sympathetic innervation of blood vessels of the limbs and abdomen is critical for the maintenance of blood pressure (BP) , particularly in standing position. In addition to this short-term sympathetic mechanism, humoral mechanisms such as the vasopressin and renin-angiotensin-aldosterone system are important for long-term maintenance of BP. The main cardiovascular reflex controlling BP is the arterial baroreflex . The arterial baroreceptors respond to pulsatile blood pressure, and they are located in the carotid sinus,