Digestive System Malignancies

By Constantine P. Spanos

Digestive System Malignancies provides an up-to-date overview on the most relevant diagnostic techniques, staging of malignancies, and current therapeutic modalities for digestive system malignancies. With coverage from esophageal, gastric and pancreatic cancers, to colon, anal and peritoneal surface, this reference offers a wide-ranging guide to malignancies throughout the digestive system. The use of engaging infographics provides an "at-a-glace" perspective on the subject, allowing users to retain a large amount of information without scrolling through large text or complex algorithms. This is an important reference for clinicians, surgeons, medical students and scientists that need a quick reference on digestive system malignancies.

• Includes comprehensive coverage of all gastrointestinal malignancies
• Provides in-depth coverage of mechanisms, helping users to quickly recognize the indications that are connected to specific medical conditions
• Spans the epidemiology, diagnostic modalities, staging, classification systems and therapy of digestive system malignancies
• Presents infographics with engaging visuals that allow users to retain a large amount of information without the need to scroll through large text or complex algorithms

• Language: English
• Publisher: Academic Press
• Release date: Feb 16, 2022
• ISBN: 9780323985758

Constantine P. Spanos

Constantine P. Spanos completed medical school in 1992, matriculating from the Aristotelian University School of Medicine. After an internship year at the Mayo Clinic in Rochester, Minnesota, he trained in General Surgery at Tufts Medical Center in Boston, Massachusetts. He then pursued fellowship training in Colon & Rectal Surgery at the University of Southern California in Los Angeles. Upon completion of his training, he returned to Greece where he is currently Associate Professor of Surgery at the Aristotelian University in Thessaloniki, Greece. He obtained his Master of Business Administration Degree (MBA) at the American College of Thessaloniki in 2018. He is currently certified (and recertified) by the American Board of Surgery and the American Board of Colon & Rectal Surgery and is an Associate Professor of Surgery at the Aristotelian University in Thessaloniki, Greece.

Book preview

Chapter 1: Esophageal cancer

Abstract

Esophageal cancer is the eighth commonest solid organ tumor worldwide and the sixth most common cause of cancer death. There are two main histologic types of esophageal cancer: squamous cell cancer (SCC) and adenocarcinoma (AC). Globally, SCC is the most common type; the incidence of adenocarcinoma has surpassed SCC in Western countries. When esophageal cancer presents with clinical symptoms, it is usually at an advanced stage. Esophageal cancer is locally advanced, metastatic or incurable in 50%–80% of cases on presentation. The Siewert classification is used for tumors in the vicinity of the EG junction. They encompass all tumors with an epicenter within 5 cm proximal/distal to the EG junction; all are adenocarcinomas. Pretreatment staging is an essential step in the management of esophageal cancer. Therapy is based on pretreatment staging assessment. Treatment incudes esophagectomy, endoscopic resection, and esophageal-sparing modalities (endoscopic mucosal ablation, radiofrequency ablation, photodynamic therapy, and cryotherapy). Neoadjuvant therapy (chemotherapy + radiation) is employed in locally advanced