Histopathology of Chronic Constipation
By W.A. Meier-Ruge and E. Bruder
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Histopathology of Chronic Constipation - W.A. Meier-Ruge
Histopathology of Chronic Constipation
Histopathology of
Chronic Constipation
William A. Meier-Ruge, Basel
Elisabeth Bruder, Basel
105 figures, 93 in color, 6 tables, 2012
logo.jpgSecond revised edition of Meier-Ruge WA, Bruder E: Pathology of Chronic Constipation in Pediatric and Adult Coloproctology. Basel, Karger, 2005.
For this book the authors thank for the generous financial support of the Freiwillige Akademische Gesellschaft Basel.
Library of Congress Cataloging-in-Publication Data
Meier-Ruge, W. (William)
Histopathology of chronic constipation / William A. Meier-Ruge, Elisabeth Bruder. -- 2nd rev. ed.
p.; cm.
Rev. ed. of: Pathology of chronic constipation in pediatric and adult coloproctology / William A. Meier-Ruge, Elizabeth Bruder. 2005.
Includes bibliographical references and index.
ISBN 978-3-318-02174-5 (hard cover: alk. paper) -- ISBN 978-3-318-02175-2 (electronic)
I. Bruder, Elisabeth. II. Meier-Ruge, W. (William). Pathology of chronic constipation in pediatric and adult coloproctology. III. Title.
[DNLM: 1. Chronic Disease. 2. Constipation--pathology. 3. Colonic Diseases--diagnosis. 4. Diagnosis, Differential. WI 409]
616.3’4280472--dc23
2012023033
S. Karger
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Contents
Foreword
Preface
Introduction
A Histopathological Diagnosis
A.1 Enzyme Histochemical Differential Diagnosis in Chronic Constipation
A.2 Functional Histopathological Differential Diagnosis in Colonic Motility Disorder
B Different Colon Diseases with Chronic Constipation
B.1 Pathogenesis of Hirschsprung’s Disease
B.2 ‘Swiss-Roll Technique’
B.3 Intraoperative Evaluation of the Myenteric Plexus
B.4 Ultrashort Hirschsprung’s Disease
B.5 Total Aganglionosis of the Colon
B.6 Hypoganglionosis of the Colon
B.7 Immaturity of the Enteric Nervous System in Childhood
B.8 Intestinal Neuronal Dysplasia Type A
B.9 Intestinal Neuronal Dysplasia Type B
B.10 Ganglioneuromatosis. Multiple Endocrine Neoplasia 2B (MEN 2B)
B.11 Desmosis Coli
B.12 Architectural Malformation of the Muscularis Propria
B.13 Degenerative Leiomyopathy: A Rare Disease
B.14 Stretching Atrophy of Circular and Longitudinal Muscles in the Gut
B.15 Nerve Cell Heterotopias in Mucosa and Muscularis Propria
C A Laboratory Guide to Histopathological Diagnosis of Intestinal Motility Disorders
C.1 The Most Important Technical Factors for Optimal Pathohistological Results
C.2 Recommendations for Taking Mucosal Biopsies in Chronic Constipation
C.3 Instructions for Transportation of Colorectal Biopsies or Surgical Specimens
D Preparation of Cryostat Sections from Biopsies and Colorectal Specimens
D.1 The Problem of Section Thickness
D.2 Preparation of Incubation Media for the Daily Routine of Enzyme Histochemical Reactions
E Immunohistochemical Techniques of Paraffin Sections in the Diagnosis of Gut Dysmotility
References
Index
Abbreviations
Foreword
In 2005, the Journal of Pathobiology (vol. 72) published a review about the pathohistology of motility disorders of the gut. This publication about the morphology of chronic constipation had a remarkable echo. Now, 7 years later, it seemed to be the time to write an update so as to incorporate the new data which has become available since that review. This book represents more than 40 years of experience in rectocolic biopsy diagnostics of gut motility disorders. Pathologists will find much diagnostic information in the field of chronic constipation, often considered as a functional disease without a morphological substrate.
It became obvious that not only an aganglionosis (Hirschsprung’s disease), but also a lack or atrophy of the tendinous collagen net in circular and longitudinal muscles may cause an aperistaltic syndrome.
Enzyme histochemistry has proven to be the pathophysiological technique of choice in the pathology of chronic constipation. This method provides insights into gastrointestinal motility disorders by the cholinergic nervous system and the dehydrogenase activity of nerve cells in the submucous and myenteric plexus. The dehydrogenases of the citric circle selectively stain nerve cells in the intestinal wall. Nitroxide synthase helps the pathologist in immediate sections for microscopic examination under surgery to reliably inform the pediatric surgeon whether the planned resection margin is aganglionic, hypoganglionic, or normal innervated.
Enzyme histochemistry overcomes the often frustrating results of classical histological stainings in formalin-fixed biopsies. Besides classical Hirschsprung’s disease, it is also possible to differentiate in mucosal biopsies ultrashort Hirschsprung’s disease, immaturity of the enteric nervous system, and neuronal dysplasia.
A laboratory guide provides instructions on how to prepare colorectal biopsies or surgical specimens, and how to transport them to the histopathological laboratory over long distances. The most important enzyme histochemical reactions in the diagnosis of gastrointestinal biopsies are also described. A final section briefly outlines immunohistochemical techniques in paraffin sections of formalin-fixed tissue. Immunohistochemistry is a static staining technique like any other histological staining (e.g.