Clinical Updates in the Management of Severe Asthma: New Strategies for Individualizing Long-term Care

By Reynold A. Panettieri, Jr., MD and Michael E. Wechsler, MD, MMSc

This eHealth Source™ program examines best practices for assessing disease control in patients with severe asthma, the evidence for current and emerging biologic medications, and strategies to improve patient education and treatment adherence.

• Language: English
• Publisher: Integritas Communications
• Release date: Feb 23, 2018
• ISBN: 9780998419404

Book preview

CLINICAL UPDATES IN THE MANAGEMENT OF SEVERE ASTHMA

New Strategies for Individualizing Long-term Care

Reynold A. Panettieri, Jr., MD and Michael E. Wechsler, MD, MMSc

INTEGRITAS COMMUNICATIONS, LLC

© 2017-2018 Integritas Communications.

All rights reserved. No part of this syllabus may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embedded in articles or reviews.

TABLE OF CONTENTS

Faculty: Reynold A. Panettieri, Jr., MD

Michael E. Wechsler, MD, MMSc

Preamble: Target Audience

Statement of Need/Program Overview

References

Educational Objectives

Physician Accreditation Statement

Physician Credit Designation

Nurse Practitioner Continuing Education

Global Contact Information

Instructions to Receive Credit

Fee Information and Refund/Cancellation Policy

Disclosure of Conflicts of Interest

Disclosure of Unlabeled Use

Disclaimer

Chapter 1: The Causes and Consequences of Severe Asthma

Burdens of Severe Asthma

Asthma Pathophysiology and New Therapeutic Targets

Key Clinical Highlights

References

Chapter 2: Comprehensive Assessment of Patients With Severe Asthma

Exacerbations and Complicating Comorbidities

Assessing Asthma Control

Using Biomarkers to Define Asthma Phenotypes and Endotypes

Key Clinical Highlights

References

Chapter 3: Biologic Therapies for Severe Asthma

Anti-IgE Therapy

Inhibitors of IL-5 Signaling

Inhibitors of IL-13 or IL-13/IL-4 Signaling

Additional Biologic Therapies for Various Severe Asthma Phenotypes

Concluding Comments

Key Clinical Highlights

References

Chapter 4: Nonbiologic Strategies for the Management of Severe Asthma

Newer Treatment Modalities for Severe Asthma

Tiotropium

Allergen Immunotherapy

Bronchial Thermoplasty

Strengthening the Therapeutic Alliance Between Patients and Providers

Promoting Patient Education and Shared Decision-Making

Improving Adherence to Therapeutic Regimens

Key Clinical Highlights

References

Severe Asthma Clinical Resource Center™: Guidelines

Patient Resources

Clinical Assessment Tools

Suggested Reading

CME Posttest

FACULTY

REYNOLD A. PANETTIERI, JR., MD

Professor of Medicine

Robert Wood Johnson Medical School

Vice Chancellor, Clinical & Translational Science

Director, Rutgers Institute for Translational Medicine & Science

Child Health Institute of New Jersey

Rutgers, The State University of New Jersey

New Brunswick, New Jersey

Reynold A. Panettieri, Jr, MD, is the Director of the Institute for Translational Medicine and Science and Vice Chancellor for Translational Medicine and Science at Rutgers University, and the former Director of the Airways Biology Initiative at the University of Pennsylvania. His interests are in the cellular and molecular mechanisms that regulate airway smooth muscle cell growth and the immunobiology of airway smooth muscle. Consequences of increases in airway smooth muscle growth promote the development of irreversible airflow obstruction and airway remodeling seen in patients with chronic severe asthma. Dr. Panettieri’s lab also focuses on cytosolic signaling pathways that mediate gene expression and alter myocyte function.

Dr. Panettieri also served as the Deputy Director of the Center of Excellence in Environmental Toxicology. He directed the human exposure chamber that defines the molecular mechanisms regulating ozone- and particulate matter-induced airway hyperresponsiveness. In parallel with his basic science interests, Dr. Panettieri managed the comprehensive clinical program for the care of patients with asthma and is actively involved in clinical investigations focused on the management of asthma and chronic obstructive pulmonary disease (COPD).

In addition to his research and clinical interests, Dr. Panettieri served as chairperson of the National Institutes of Health (NIH) Lung Cellular, Molecular, and Immunobiology Study Section, is a member of the NIH Distinguished Editorial Panel, and is a member of both the American Society for Clinical Investigation and Association of American Physicians.

MICHAEL E. WECHSLER, MD, MMSC

Co-Director, The Cohen Family Asthma Institute

Professor, Department