Genetics of Bone Biology and Skeletal Disease
()
Currently unavailable
Currently unavailable
About this ebook
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders.
The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models.
The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets.
- Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments
- Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders
- Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Related to Genetics of Bone Biology and Skeletal Disease
Related ebooks
Osteoimmunology: Interactions of the Immune and Skeletal Systems Rating: 0 out of 5 stars0 ratingsEmery and Rimoin’s Principles and Practice of Medical Genetics and Genomics: Metabolic Disorders Rating: 0 out of 5 stars0 ratingsGenetics, revised edition: A Guide for Students and Practitioners of Nursing and Health Care Rating: 0 out of 5 stars0 ratingsBiochemical Disorders of the Skeleton: Postgraduate Orthopaedics Series Rating: 0 out of 5 stars0 ratingsCancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity Rating: 0 out of 5 stars0 ratingsChromatin Signaling and Neurological Disorders Rating: 0 out of 5 stars0 ratingsEmery and Rimoin’s Principles and Practice of Medical Genetics and Genomics: Hematologic, Renal, and Immunologic Disorders Rating: 0 out of 5 stars0 ratingsEpigenetic Gene Expression and Regulation Rating: 3 out of 5 stars3/5Immunobiology of the Complement System: An Introduction for Research and Clinical Medicine Rating: 3 out of 5 stars3/5Disease and Its Causes Rating: 0 out of 5 stars0 ratingsBacteria in Daily Life Rating: 4 out of 5 stars4/5The Dictionary of Cell & Molecular Biology Rating: 0 out of 5 stars0 ratingsThe Biochemistry and Physiology of Bone Rating: 0 out of 5 stars0 ratingsThe Biogenesis of Mitochondria: Transcriptional, Translational and Genetic Aspects Rating: 0 out of 5 stars0 ratingsThe Amphibian Visual System: A Multidisciplinary Approach Rating: 0 out of 5 stars0 ratingsTeratogens: Chemicals Which Cause Birth Defects Rating: 0 out of 5 stars0 ratingsAntigens, Lymphoid Cells and the Immune Response Rating: 0 out of 5 stars0 ratingsElementary Medical Biochemistry Rating: 0 out of 5 stars0 ratingsMating Systems and Strategies Rating: 4 out of 5 stars4/5Advances in Clinical Cytology Rating: 2 out of 5 stars2/5The Endocrine System Rating: 0 out of 5 stars0 ratingsResearch Surgery and Care of the Research Animal: Surgical Approaches to the Organ Systems Rating: 0 out of 5 stars0 ratingsThe Science of Stem Cells Rating: 0 out of 5 stars0 ratingsDNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications Rating: 0 out of 5 stars0 ratingsRetrovirus-Cell Interactions Rating: 0 out of 5 stars0 ratingsVenomous Animals and Their Venoms: Venomous Invertebrates Rating: 0 out of 5 stars0 ratingsTranslating MicroRNAs to the Clinic Rating: 5 out of 5 stars5/5Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases Rating: 0 out of 5 stars0 ratingsMolecular Biology of Plants Rating: 0 out of 5 stars0 ratingsCells and Tissues in Culture: Methods, Biology and Physiology Rating: 0 out of 5 stars0 ratings
Medical For You
The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5ATOMIC HABITS:: How to Disagree With Your Brain so You Can Break Bad Habits and End Negative Thinking Rating: 5 out of 5 stars5/5Mating in Captivity: Unlocking Erotic Intelligence Rating: 4 out of 5 stars4/5The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Rating: 5 out of 5 stars5/5Passionista: The Empowered Woman's Guide to Pleasuring a Man Rating: 4 out of 5 stars4/5Mediterranean Diet Meal Prep Cookbook: Easy And Healthy Recipes You Can Meal Prep For The Week Rating: 5 out of 5 stars5/5Adult ADHD: How to Succeed as a Hunter in a Farmer's World Rating: 4 out of 5 stars4/5Tight Hip Twisted Core: The Key To Unresolved Pain Rating: 4 out of 5 stars4/5The 40 Day Dopamine Fast Rating: 4 out of 5 stars4/5The White Coat Investor: A Doctor's Guide to Personal Finance and Investing Rating: 4 out of 5 stars4/5WomanCode: Perfect Your Cycle, Amplify Your Fertility, Supercharge Your Sex Drive, and Become a Power Source Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Living Daily With Adult ADD or ADHD: 365 Tips o the Day Rating: 5 out of 5 stars5/5What Happened to You?: Conversations on Trauma, Resilience, and Healing Rating: 4 out of 5 stars4/5The Amazing Liver and Gallbladder Flush Rating: 5 out of 5 stars5/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5Period Power: Harness Your Hormones and Get Your Cycle Working For You Rating: 4 out of 5 stars4/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5Hidden Lives: True Stories from People Who Live with Mental Illness Rating: 4 out of 5 stars4/5ketoCONTINUUM Consistently Keto For Life Rating: 5 out of 5 stars5/5Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies Rating: 4 out of 5 stars4/5Women With Attention Deficit Disorder: Embrace Your Differences and Transform Your Life Rating: 5 out of 5 stars5/5Blind Eye: The Terrifying Story Of A Doctor Who Got Away With Rating: 4 out of 5 stars4/5The Art of Dying Well: A Practical Guide to a Good End of Life Rating: 4 out of 5 stars4/5
Related categories
Reviews for Genetics of Bone Biology and Skeletal Disease
0 ratings0 reviews