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Ebook455 pages10 hours
Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development
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About this ebook
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
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Titles in the series (9)
Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications Rating: 0 out of 5 stars0 ratingsIntegrated Strategies for Drug Discovery Using Mass Spectrometry Rating: 0 out of 5 stars0 ratingsCharacterization of Impurities and Degradants Using Mass Spectrometry Rating: 0 out of 5 stars0 ratingsMass Spectrometry Handbook Rating: 0 out of 5 stars0 ratingsDried Blood Spots: Applications and Techniques Rating: 0 out of 5 stars0 ratingsOral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development Rating: 0 out of 5 stars0 ratingsTargeted Biomarker Quantitation by LC-MS Rating: 0 out of 5 stars0 ratingsProtein Analysis using Mass Spectrometry: Accelerating Protein Biotherapeutics from Lab to Patient Rating: 0 out of 5 stars0 ratingsSample Preparation in LC-MS Bioanalysis Rating: 0 out of 5 stars0 ratings
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