Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy

By Gang Ho Lee and Jeong-Tae Kim

Most books discuss general and broad topics regarding molecular imagings. However, Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy, will mainly focus on lanthanide oxide nanoparticles for molecular imaging and therapeutics. Multi-modal imaging capabilities will discussed, along with up-converting FI by using lanthanide oxide nanoparticles. The synthesis will cover polyol synthesis of lanthanide oxide nanoparticles, Surface coatings with biocompatible and hydrophilic ligands will be discussed and TEM images and dynamic light scattering (DLS) patterns will be provided. Various techniques which are generally used in analyzing the synthesized surface coated nanoparticles will be explored and this section will also cover FT­, IR analysis, XRD analysis, SQUID analysis, cytotoxicity measurements and proton relaxivity measurements. In vivo MR images, CT images, fluorescence images will be provided and Therapeutic application of gadolinium oxide nanoparticles will be discussed. Finally, future perpectives will be discussed. That is, present status and future works needed for clinical applications of lanthanide oxide nanoparticles to molecular imagings will be discussed.

• Synthesis will be discussed in detail
• General characterizations of nanoparticles before in vivo applications will be discussed
• The book will cover all possible applications of lanthanide oxide nanoparticles to molecular imagings such as MRI, CT, FI as well as therapeutics

• Language: English
• Publisher: Elsevier Science
• Release date: Nov 22, 2014
• ISBN: 9780081000694

Gang Ho Lee

Gang Ho Lee is a professor in the Department of Chemistry at the College of Natural Sciences, Kyungpook National University, Teagu, South Korea.

Book preview

Ultrasmall lanthanide oxide nanoparticles for biomedical imaging and therapy

First Edition

Gang Ho Lee

Yongmin Chang

Tae-Jeong Kim

Table of Contents

Cover image

Title page

Copyright page

Dedication

List of figures and tables

List of abbrevations

Acknowledgments

Preface

About the authors

1: Introduction to biomedical imaging

Abstract

1.1 What is biomedical imaging?

1.2 Various imaging modalities now available

1.3 References

2: Properties and possible application areas

Abstract

2.1 Introduction

2.2 Possible application areas

2.3 References

3: Synthesis and surface modification

Abstract

3.1 Synthesis

3.2 Surface coating

3.3 Other lanthanide nano-systems

3.4 References

4: Characterization

Abstract

4.1 Introduction

4.2 Particle diameter and morphology

4.3 Crystal structure

4.4 Hydrodynamic diameter (a)

4.5 Surface coating confirmation

4.6 Surface coating amount

4.7 Magnetic properties

4.8 Cytotoxicity

4.9 Water proton relaxivity and map image

4.10 Biodistribution

4.11 In vivo TEM analysis of nanoparticles

4.12 Fluorescent properties

4.13 References

5: MRI, CT, FI, and multi-modal imaging and images

Abstract

5.1 Magnetic resonance imaging (MRI) and images

5.2 X-ray computed tomography (CT) and images

5.3 Fluorescent imaging (FI) and images

5.4 Multi-modal imaging

5.5 References

6: A simple model calculation of water proton relaxivities

Abstract

6.1 Introduction

6.2 Magnetization

6.3 Longitudinal water proton relaxation (T1) and relaxivity (r1)

6.4 Transverse water proton relaxation (T2) and relaxivity (r2)

6.5 Concluding remarks

6.6 References

7: Thermal neutron capture therapy (NCT)

Abstract

7.1 Introduction

7.2 BNCT

7.3 GdNCT

7.4 References

8: Perspectives and challenges

Abstract

8.1 Perspectives and challenges

8.2 What needs to be done for clinical applications

Index

Copyright

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Notice

No responsibility is assumed by the publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made.

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library

Library of Congress Control Number: 2014946710

ISBN 978-0-08100-066-3 (print)

ISBN 978-0-08100-069-4 (online)

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Printed and bound in the United Kingdom

Dedication

To my family:

Gang Ho Lee

List of figures and tables

Figures

Tables