Alzheimer's Disease: The Complete Introduction
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About this ebook
A guide for caregivers and sufferers coping with Alzheimer’s.
Alzheimer’s disease is a reality in millions of lives and a serious concern for seniors and their loved ones. In developed countries where people are living longer than ever before, the incidence of Alzheimer’s is reaching epidemic proportions, according to the World Health Organization. For families, sufferers, and caregivers, the need for reliable, clear, and concrete information has never been greater.
Alzheimer’s Disease: The Complete Introduction is a comprehensive guide to the disease and its effects: getting a diagnosis, the ways it can progress and be managed, strategies for supporting sufferers and accessing care, legal concerns, and more. This guide addresses every aspect of the disease from the first doctor’s visit to the long-term measures that can drastically improve the lives of sufferers and those close to them.
Inside, you will find:
- Practical and comprehensive information to guide every step of the process of seeking treatment or a diagnosis
- A reassuring, realistic guide for family members, caregivers, and patients themselves
- Answers to the most commonly asked and most pressing questions about Alzheimer’s
- Detailed and clear chapters on the lifestyle habits that may aid in preventing and managing Alzheimer’s
Written by two medical experts, this guide is intended for all. It aims to demystify the disease and provide a clear path to reclaiming stability and quality of life. Finally, it explains the real progress that has been made over the past five years in treatment and prevention.
Judes Poirier
Dr. Judes Poirier is a professor of medicine and psychiatry at McGill, and director of the molecular neurobiology unit at the Douglas Mental Health University Institute. His pioneering work in biomedical research into the causes and treatments of Alzheimer's and Parkinson's disease has earned him several prestigious awards. He lives in Blainville, Quebec.
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Reviews for Alzheimer's Disease
3 ratings1 review
- Rating: 2 out of 5 stars2/5Useful only as a very general introduction to the disease. Patients and families will will quickly find that this isn't going to answer their questions.
Book preview
Alzheimer's Disease - Judes Poirier
Works on Alzheimer’s by the Same Authors
Poirier, Judes, ed. Apoptosis: Techniques and Protocols.
Neuromethods 29. New York: Humana Press, 1997.
Gauthier, S., A. Burns, and W. Petit. Alzheimer’s Disease in
Primary Care. London: Martin Dunitz, 1997.
Gauthier, S., A. Burns, and W. Petit. La Maladie d’Alzheimer
en Médecine Générale. London: Martin Dunitz, 1997.
Gauthier, S., ed. Pharmacotherapy of Alzheimer’s Disease.
London: Martin Dunitz, 1998.
Gauthier, S., ed. Clinical Diagnosis and Management of Alzheimer’s
Disease. Rev. 2nd ed. London: Martin Dunitz, 2001.
Erkinjutti, T. and S. Gauthier, ed. Vascular Cognitive Impairment.
London: Martin Dunitz, 2002.
Gauthier, S., P. Scheltens, and J. Cummings, ed. Alzheimer’s Disease and
Related Disorders. London: Martin Dunitz/Taylor & Francis, 2005.
Gauthier S., ed. Clinical Diagnosis and Management of Alzheimer’s Disease.
3rd ed. London: Informa Healthcare, 2007.
Wahlund, L.O., T. Erkinjutti, and S. Gauthier, ed. Vascular Cognitive Impairment
in Clinical Practice. Cambridge: Cambridge University Press, 2009.
Gauthier, S. and C. Ballard. Management of Dementia. London:
Informa Healthcare, 2009.
This book is dedicated to Francine, Louise, Thérèse, Éric,
Judith, Catherine, and Alexandre for having helped
us stay the course through the ups and downs of life.
Contents
Cover
Alzheimer's Disease
Dedication
Contents
Foreword
Introduction
Chapter One
Chapter Two
Chapter Three
Chapter Four
Chapter Five
Chapter Six
Chapter Seven
Chapter Eight
Chapter Nine
Conclusion
Afterword
For Further Reading
Bibliography
About the Author
Credits
Copyright
INTRODUCTION
Alzheimer’s Disease in
the Baby Boomer Era
The medical profession has, for many years, tended to associate gradual memory loss with normal aging. Hence the surprising statistic that more than 50 percent of people with mild Alzheimer’s disease are not diagnosed, or are diagnosed but not treated. It is important to realize that, for a long time, the large family of dementias to which Alzheimer’s disease belongs, was of little or no interest to doctors, as its main symptoms were considered to be the natural consequences of aging.
Not everyone deemed Alzheimer’s to be a disease in the true sense of the word — one with a predictable clinical progression and measurable symptoms. It was instead seen as the consequence of growing older. Often, the initial symptoms have only a very small impact on a person’s day-to-day activities. It is thus quite rare to see individuals in the mild stage go by themselves to the doctor to discuss their symptoms. Usually someone close to the person (the spouse or a relative) convinces the person that he or she needs to have a doctor assess the situation. In the affected person’s mind everything seems fine and there is no need to see a doctor.
Figure 1 illustrates the progression of the major symptoms of Alzheimer’s disease. As can be seen, the first phase, in which brain damage occurs very slowly over one or two decades, is silent, with no visible symptoms. When the first symptoms (such as a decline in short-term memory or the need to search for words) appear, the disease can be diagnosed. It is not uncommon at this stage for the patient or family to postpone seeing a doctor due to the belief that memory loss is completely normal in people of a certain age.
It has been observed that memory disorders tend to be predominant at the outset of the disease and become worse during the early years. Then follows a gradual loss of functional independence — the ability to manage one’s finances, drive a car, prepare meals, and, eventually, take care of oneself and attend to one’s basic needs. Later, behavioural problems quite often appear, varying both from one individual to another and by gender. Specifically, these include spontaneous outbursts of anger, aggressiveness, or, conversely, apathy and lack of interest. In the later stages, motor problems develop in a large portion of people affected, depriving them of their physical independence.
As can be seen, Alzheimer’s is much more than a disease of the memory. It develops slowly in those sixty-five and older and affects regions of the brain where memory, learning, judgement, emotions, and even movement are controlled. And the fact is that the first baby boomers, the vanguard of the anticipated wave of aging adults who were born after World War II, have just turned sixty-five. The disease is expected to become more and more prevalent in the coming years.
This book offers a detailed analysis of the current state of the disease, its progression over time, and the efforts being made by various medical bodies to slow its progression or effectively manage some of its most problematic symptoms. Above all, the book tries to demystify the disease as a whole and to answer the most common questions asked by patients or members of their family. It presents a systematic review of more than a hundred years of medical research, including both the promising and not-so-promising results. It offers a regional and global view of Alzheimer’s disease today and the choices our society will have to face in the relatively near future.
This book provides an overview of the latest medical and scientific news about recent progress in research, the causes of and treatments for Alzheimer’s disease, approaches to prevention that are being developed, and lifestyle habits that have been scientifically validated and may slow down or hinder the symptomatic progression of the disease. Among the many factors discussed are diet and exercise, two personal choices requiring neither a visit to the doctor nor a prescription.
Recent demographic data collected by various Alzheimer’s societies around the world paint a rather dismal picture of the next three decades: ever more people affected, astronomical health-care costs, treatments that appear to have only limited effects, and half-hearted investment in research. Knowing this, we felt it was all the more important to explain the situation more fully to readers, to dispel certain myths that persist even today, and to describe, in a more humane way, the various stages of the disease and the choices a family must make at each step of the way. In short, we felt we had to tell it like it is, without being alarmist or getting caught up in hollow debates.
The medical community understands the disease much better than it did five years ago. We have gone from the stage where detecting the disease was difficult to developing sophisticated prevention strategies. It is this new understanding of causes and treatments that we want to share with readers in a non-technical, easily accessible way.
Foreword
If there is one subject that has been constantly on my mind for several years, it’s Alzheimer’s disease, for my wife, Lucie, is suffering from it. Like many families, we are coping with the situation and learning to mourn the loss of a number of pleasures that only death should have taken away. Communication, closeness, and shared dreams are no longer possible. Of course, Lucie is not the only person with this disease. There are forty million victims worldwide, and that number is expected to reach eighty million in the space of a generation.
Alzheimer’s disease is beginning to take on epidemic proportions and will severely affect Canadians, given our aging population. To paraphrase Jean de La Fontaine, the famous writer of fables, it’s safe to say that while not everyone will personally fall victim to the disease, we will all be affected by it. Without question, each of us will see members of our family or immediate circle diagnosed and in need of care.
On a daily basis, caregivers need encouragement, support, and advice to help them fulfill their role and make good decisions. As for the upcoming generation, they need to know whether research is progressing and whether they can hope for a less worrying future than that of their parents and grandparents. This book provides answers to both questions in clear and easily understood terms. It offers advice to caregivers and dispels myths by providing accurate data and medical explanations to help younger readers understand.
Well-known for their expertise in this field, Drs. Judes Poirier and Serge Gauthier have successfully taken stock of both past and current research, even making a brief foray into the future. Their approach to the aspects of the disease is straightforward and rigorous. Genetics, risk factors, making a diagnosis, the progression of the disease, treatments, prevention — it’s all here. We are very lucky that many researchers and clinicians are devoting so much energy to advancing research in this field, and the information provided by the authors offers a kind of comforting reassurance.
If I could have one wish, it would be for the book Alzheimer’s Disease: The Complete Introduction to find its way into people’s homes even before the onset of symptoms. There is a very simple reason for this: it is much easier to deal with the subject in a family when no one has the disease. A person who waits until he suspects his spouse is showing signs of the disease before reading this book may be running the risk of eliciting an angry reaction when the spouse sees what he has been reading. All needless conflict situations involving a person with Alzheimer’s disease must be avoided, in favour of an understanding, respectful, and loving approach. We have to realize that the vast majority of people in the initial phase of the disease tend to deny they have symptoms and refuse even to discuss them.
No one can claim that preventive measures are effective in every case, but they certainly can’t hurt. A healthy diet, physical exercise, and education, among others, will always guarantee a better quality of life, and they must be encouraged. Although the mission of the Lucie and André Chagnon foundation is not to prevent Alzheimer’s disease, prevention is at the heart of everything the foundation does. In every field, I believe that prevention should be the priority; this is even more the case with respect to research on Alzheimer’s disease, for the human and financial costs for our society are going to increase dramatically in the coming years.
Treatments have progressed a great deal since the disease was identified a hundred years ago, and doctors have more sophisticated ways of attending to patients. I have the opportunity to observe this every day I see Dr. Gauthier, who has been looking after my wife since 2004. Through his humane approach, he has succeeded in creating a close bond over the years, both with Lucie and with our family, for which I am profoundly grateful.
André Chagnon
Chairman and Chief Executive Officer
Lucie and André Chagnon Foundation
Professor Alois Alzheimer, circa 1910.