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  • The Atlantic

    The Ozempic Plateau

    Everyone hits a weight-loss plateau, but the race is on for next-generation drugs that can help patients lose even more weight.
    by Sarah Zhang Jan 17, 2024 5 minutes
    Source: Illustration by The Atlantic. Source: Getty.

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    The latest weight-loss drugs are rightly hailed as game changers for obesity, but in an important way, they are just like every other method of managing weight: They work only to a point for weight loss. The pounds melt off quickly at first and then gradually and then not at all. You can’t lose any more no matter what you do. You’ve hit the weight-loss plateau.

    It happens with dieting. It happens with bariatric surgery. And it happens now with both semaglutide (better known as Ozempic or Wegovy, depending on whether it’s prescribed for diabetes or weight loss) and tirzepatide (better known as Mounjaro or Zepbound). Weight loss triggers a set of powerful physiological changes in the

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