There are plenty of collectors who will tell you they have a revolving collection, often selling items at a not-so-small profit to support their hobby. And there are likely just as many who will vow “never” to sell anything, as it would be a sacrilege to even consider parting with anything.
I fall under the latter group a lot more than the former.
It simply never makes sense to sell a “holy grail” piece in the collection, certainly not those items that took years to find