Cleveland Clinic Study Did Not Show Vaccines Increase COVID-19 Risk
SciCheck Digest
Numerous studies have found that additional COVID-19 shots are generally associated with extra protection against the coronavirus. Many people on social media, however, have shared a preliminary finding from a Cleveland Clinic study and misrepresented it as proving that getting more doses increases a person’s risk of infection.
All of the authorized and approved vaccines are effective at preventing severe COVID-19.
Against earlier forms of the coronavirus, the vaccines were highly effective at preventing symptomatic illness. For example, the Pfizer/BioNTech vaccine, which was the first COVID-19 vaccine to receive full approval from the Food and Drug Administration, showed a final efficacy of 91% against symptomatic illness in its phase 3 trial, meaning that under the conditions of the trial the vaccine reduced the risk of getting sick by 91%.
The Moderna vaccine showed similar results in its clinical trial, with a final efficacy of 93%. It has also received FDA approval.
Johnson & Johnson, which partly tested its vaccine in South Africa when the beta variant emerged, reported an efficacy of 66% in preventing moderate to severe COVID-19 and an efficacy of 85% in preventing severe or critical COVID-19 in its clinical trial.
The Novavax vaccine, which was authorized in July 2022, had a 90.4% efficacy in preventing symptomatic COVID-19 in adults, prior to the emergence of the omicron variant.
Subsequent studies have demonstrated that the vaccines are effective under real-world conditions, including against the highly contagious delta variant. Against omicron, however, the vaccines haven’t fared as well and are much worse at preventing infection or mild disease. The shots are still good at preventing hospitalization or death, though, particularly if
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