High Times

Study: CBD Could Inhibit Nicotine Metabolism

nother possible benefit of CBD is good news for smokers who want to quit, but are looking examined how CBD could potentially help people quit cigarette smoking. The study, called “Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD),” examined human liver tissue and cell samples, and found that CBD inhibited a key enzyme that’s needed for nicotine metabolism. Slowing metabolism of nicotine’s key enzyme, researchers believe, could help smokers wait longer before they need to inhale more tobacco. The results of the study reported that CBD slowed activity of many nicotine enzymes, including the enzyme CYP2A6 which metabolizes more than 70% of nicotine in smokers. Researchers found that CBD inhibited the activity of CYP2A6 by 50%. Cigarette smoking remains the number one cause of preventable death in the U.S., according to the Centers for Disease Control and Prevention.

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