NPR

Typhoid mutated to beat antibiotics. Science is learning how to beat those strains

The ancient disease is still a killer. And even though there are new drugs, there's a growing rate of antibiotic-resistance cases. Here's a look at the latest strategies to tame typhoid.
Scanning electron micrograph of <em data-stringify-type="italic">Salmonella typhi</em>, the parasite that causes typhoid fever (in yellow-green, attached to another bacterial cell.

Do you remember the story of Typhoid Mary – the cook who spread typhoid to as many as 100 people in the early 1900s even though she herself showed no symptoms? She was confined to isolation for 26 years because, at the time, there weren't any treatments that could cure this so-called "healthy carrier."

Since then we've developed powerful antibiotics that could have wiped out Mary's typhoid and that have been used to successfully treat many millions with the disease.

But the ancient disease of typhoid has adapted to modern times. New antibiotic-resistant strains are on the rise, fueling outbreaks across the world and making up a greater percentage of the yearly toll of 10 to 20

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