Aster Medical Journal (AMJ)

Acute Post-streptococcal Glomerulonephritis and Acute Rheumatic Fever, Co-existing in the Same Patient

INTRODUCTION

Acute post-streptococcal glomerulonephritis (APSGN) and acute rheumatic fever (RF) are both well-recognized non suppurative sequelae of group A beta hemolytic streptococcus infections.¹ The serotypes of group A Streptococci can be divided into those with rheumatogenic and nephritogenic potential.² Post-streptococcal glomerulonephritis and rheumatic fever have different epidemiology and immunological features; their concurrent development in the same patient is very rare,³ because of their different pathophysiologic mechanisms.1,4

CASE REPORT

A 15-year-old male presented with history of fever of three weeks duration, associated with a sore throat. Twenty days after the onset of fever, he noticed puffiness of the face followed by progressive worsening of oedema involving the rest of the body. He had bilateral pedal oedema and abdominal distension, associated with dark-coloured urine and reduced urine output. He had arthralgia involving both knee joints. Urine examination showed numerous RBCs and proteinuria; Serum creatinine was 1.8mg/dl. There was a weight gain of 8 kg.

On admission to our center, the patient was febrile, and blood pressure was 130/88 mm

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