Tweaking how CAR-T therapy kills tumors could stop a dangerous side effect, study finds
CAR-Ts attack and kill cancer cells in the messiest way biologists have ever seen, but a new study suggests a safer approach.
As every trauma surgeon knows, there are messy bullet wounds and there are neat ones, and the former cause incomparably more trouble. If a team of scientists in China is right, the same principle may explain why the genetically engineered CAR-T cells that have been so successful against some leukemias and lymphomas often cause a violent and even life-threatening immune reaction.
The problem, the researchers reported on Friday, is that CAR-Ts attack and kill cancer cells in the messiest way biologists have ever seen.
Viewed under a microscope, the leukemia cells targeted by CAR-Ts “died dramatically,”
