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‘It’s really a horrific situation’: What one doctor thinks about drug shortages‚ and how to solve them

Shortages of drugs like BCG for bladder cancer are caused by a manufacturing problem that can be solved, says Dr. Ben Davies.

Cutting-edge science and the development of groundbreaking and lifesaving drugs get a lot of attention, but the everyday practice of medicine is often more mundane: It doesn’t involve being CRISPR’d or having gene therapy delivered into your cells. The truth is that most people who are very sick and visit their doctor get treated with very ordinary and sometimes very old drugs.

But in recent years supplies of some of these critical standby medicines have become disrupted. The shortages have forced doctors to make hard treatment decisions. Drugs have to be rationed or, in the worst cases, patients who need care can be turned away.

Dr. Ben Davies is a professor of urology at the University of Pittsburgh and a BioTwitter influencer (“I don’t think anyone has ever called me a BioTwitter influencer before,” he says.). Davies recently chatted with STAT about the recurring problem of drug shortages.

You’ve had experience with shortages of a medicine called . What’s the history of BCG

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