NPR

Mosquitoes Genetically Modified To Crash Species That Spreads Malaria

Scientists demonstrate that a "gene drive" can rapidly spread a genetic mutation through a species, perhaps providing a potent new weapon against malaria. But there are plenty of skeptics.
This adult <em>Anopheles gambiae</em> mosquito — the kind that spreads malaria — was genetically modified as part of the study.

For the first time, scientists have demonstrated that a controversial new kind of genetic engineering can rapidly spread a self-destructive genetic modification through a complex species.

The scientists used the revolutionary gene-editing tool known as CRISPR to engineer mosquitoes with a "gene drive," which rapidly transmitted a sterilizing mutation through other members of the mosquito's species.

After mosquitoes carrying the mutation were released into cages filled with unmodified mosquitoes in a high-security basement laboratory in London, virtually all of the insects were wiped out, according to a report in Nature Biotechnology.

The were created in the hopes of using them as a potent new weapon in the long, frustrating fight against malaria. remains one of the world's deadliestdiseases, killing more than 400,000 people every year, mostly children younger than five years old.

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