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    Terpenes
    Alkaloids and Other Nitrogen-Containing Derivatives
    Flavonoids and Phenolics
    Ebook series3 titles

    Medicinal Chemistry Lessons From Nature Series

    By Simone Carradori

    ()

    About this series

    Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.
    This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.
    Volume 3 presents (1) a brief overview of botanical and pharmacological properties of alkaloids, (2) a summary of the synthesis of natural morphinans and related alkaloids, (3) caffeine-based compounds for the treatment of neurodegenerative disorders, (4) piperine derivatives, (5) noscapine-based anti-cancer agents, (6) biogenic amines and amino acid derivatives as carbonic anhydrase modulators and (7) antimalarial compounds on quinoline scaffolds.
    The objective of this book is to fulfil gaps in current knowledge with updated information from recent years. It serves as a guide for academic and professional researchers and clinicians.

    LanguageEnglish
    PublisherBentham Science Publishers
    Release dateOct 7, 2003
    Terpenes
    Alkaloids and Other Nitrogen-Containing Derivatives
    Flavonoids and Phenolics

    Titles in the series (3)

    • 1

      Flavonoids and Phenolics
      Flavonoids and Phenolics

      Flavonoids and Phenolics

      PublishDrive
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      Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Each chapter follows a specific format for a phytochemical agent with common chemical features: • General background on the (phyto)chemistry of the scaffold • General background on the pharmacological profile of the scaffold • A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships) • In silico analysis of the crucial interactions with the biological target • Clinical studies and patent survey (if available) on the new and proposed structures The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

      Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Each chapter follows a specific format for a phytochemical agent with common chemical features: • General background on the (phyto)chemistry of the scaffold • General background on the pharmacological profile of the scaffold • A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships) • In silico analysis of the crucial interactions with the biological target • Clinical studies and patent survey (if available) on the new and proposed structures The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

    • 2

      Terpenes
      Terpenes

      Terpenes

      PublishDrive
      0 ratings
      0 ratings

      Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Volume 2 presents (1) a detailed overview of the polypharmacology of sesquiterpenes, (2) an interesting journey around the globe of cannabinoids revealing the development of new synthetic Δ9-THC derivatives, (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils, (4) an update on the latest generation of endoperoxides that display antimalarial activity and, finally, (5) a summary of MedChem strategies to fix common issues faced in formulating terpene derivatives (such as low potency and poor solubility). The objective of this book is to fulfil gaps in current knowledge with updated information from recent years. It serves as a guide for academic and professional researchers and clinicians.

      Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Volume 2 presents (1) a detailed overview of the polypharmacology of sesquiterpenes, (2) an interesting journey around the globe of cannabinoids revealing the development of new synthetic Δ9-THC derivatives, (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils, (4) an update on the latest generation of endoperoxides that display antimalarial activity and, finally, (5) a summary of MedChem strategies to fix common issues faced in formulating terpene derivatives (such as low potency and poor solubility). The objective of this book is to fulfil gaps in current knowledge with updated information from recent years. It serves as a guide for academic and professional researchers and clinicians.

    • 3

      Alkaloids and Other Nitrogen-Containing Derivatives
      Alkaloids and Other Nitrogen-Containing Derivatives

      Alkaloids and Other Nitrogen-Containing Derivatives

      Simone Carradori
      0 ratings
      0 ratings

      Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Volume 3 presents (1) a brief overview of botanical and pharmacological properties of alkaloids, (2) a summary of the synthesis of natural morphinans and related alkaloids, (3) caffeine-based compounds for the treatment of neurodegenerative disorders, (4) piperine derivatives, (5) noscapine-based anti-cancer agents, (6) biogenic amines and amino acid derivatives as carbonic anhydrase modulators and (7) antimalarial compounds on quinoline scaffolds. The objective of this book is to fulfil gaps in current knowledge with updated information from recent years. It serves as a guide for academic and professional researchers and clinicians.

      Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Volume 3 presents (1) a brief overview of botanical and pharmacological properties of alkaloids, (2) a summary of the synthesis of natural morphinans and related alkaloids, (3) caffeine-based compounds for the treatment of neurodegenerative disorders, (4) piperine derivatives, (5) noscapine-based anti-cancer agents, (6) biogenic amines and amino acid derivatives as carbonic anhydrase modulators and (7) antimalarial compounds on quinoline scaffolds. The objective of this book is to fulfil gaps in current knowledge with updated information from recent years. It serves as a guide for academic and professional researchers and clinicians.

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