Amniotic Fluid Embolism is a devastating and rare complication of pregnancy. The A-OK protocol is commonly advocated for as a life saving therapy in this scenario.Dr Stephanie Martin reviews the case reports and discusses her opinions on the role of A-OK in AFE management.Go to www.amnioticfluidembolism.org for access to a free educational program on AFE.Case reports referenced:Wothe JK, Elfstrand E, Mooney MR, Wothe DD. Rotational Thromboelastometry-Guided Venoarterial Extracorporeal Membrane Oxygenation in the Treatment of Amniotic Fluid Embolism. Case Rep Obstet Gynecol. 2022 May 18;2022:9658708. doi: 10.1155/2022/9658708. PMID: 35646404; PMCID: PMC9132692.Long M, Martin J, Biggio J. Atropine, Ondansetron, and Ketorolac: Supplemental Management of Amniotic Fluid Embolism. Ochsner J. 2022 Fall;22(3):253-257. doi: 10.31486/toj.21.0107. PMID: 36189093; PMCID: PMC9477128.Berry A, Salcedo A, Riba C. Atypical amniotic fluid embolism successfully treated with a novel protocol: A case report. J Case Rep Images Obstet Gynecol 2022;8:100109Z08AB2022.Rezai S, Hughes AC, Larsen TB, Fuller PN, Henderson CE. Atypical Amniotic Fluid Embolism Managed with a Novel Therapeutic Regimen. Case Rep Obstet Gynecol. 2017;2017:8458375. doi: 10.1155/2017/8458375. Epub 2017 Dec 21. PMID: 29430313; PMCID: PMC5753013.