In "No Time to Quit," Dr. Osterholm and Chris Dall discuss the JN.1 variant, Paxlovid uptake, and COVID-19 vaccine disinformation. Dr. Osterholm also provides an update on influenza and RSV transmission and shares the latest "This Week in Public Health History" segment. Opinion: The U.S. is facing the biggest COVID wave since Omicron. Why are we still playing make-believe? (Eric Topol, LA Times)Paxlovid Cuts Covid Death Risk. But Those Who Need It Are Not Taking It (Christina Jewett, New York Times)COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection (Brosseau et al., CIDRAP)