JACI: In Practice Editor-in-Chief Michael Schatz describes the December issue, the theme of which is “Adverse Effects of Drugs Used in Allergy and Immunology Practice”. Theme topics covered include an overview of the FDA labeling and approval process, FDA boxed warnings and the off-label use of medications, the safety of commonly used allergy and asthma medications in children, safety considerations for natural products commonly used by patients with allergic disease, and safety issues regarding medications for refractory chromic urticaria, biologics, proton pump inhibitors, and diphenhydramine. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of anaphylaxis, asthma, dermatitis, drug allergy, food allergy, and urticaria and angioedema. Read the issue: https://www.jaci-inpractice.org/issue/S2213-2198(21)X0024-4Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org