2024 Big Ideas: Miracle Drugs, Programmable Medicine, and AI Interpretability

Securing the Black Box: OpenAI, Anthropic, and GDM Discuss: Human nature fears the unknown, and with the rapid progress of AI, concerns naturally arise. Uncanny robocalls, data breaches, and misinformation floods are among the worries. But what about security in the era of large language models? In this episode, we hear from security leaders at OpenAI, Anthropic, and Google DeepMind. Matt Knight, Head of Security at OpenAI, Jason Clinton, CISO at Anthropic, and Vijay Bolina, CISO at Google DeepMind, are joined by Joel de la Garza, operating partner at a16z and former chief security officer at Box and Citigroup. Together, they explore how large language models impact security, including changes in offense and defense strategies, misuse by nation-state actors, prompt engineering, and more. In this changing environment, how do LLMs transform security dynamics? Let's uncover the answers. by a16z Podcast

60 min listen

Can AI Advance Science? DeepMind's VP of Science Weighs In: In recent years, the AI landscape has seen huge advancements, from the release of Dall-E 2 in April 2022 to the emergence of AI music and video models in early 2024. While creative tools often steal the spotlight, AlphaFold 2 marked a groundbreaking AI breakthrough in biology in 2021. Since its release, this pioneering tool for predicting protein structures has been utilized by over 1.7 million scientists worldwide, influencing fields ranging from genomics to computational chemistry. In this episode, DeepMind's VP of Research for Science, Pushmeet Kohli, and a16z General Partner Vijay Pande discuss the transformative potential of AI in scientific exploration. Can AI lead to fundamentally new discoveries in science? Let's find out. by a16z Podcast

56 min listen

Next-Gen Gaming: AI Souls, Real-time Culture, Personalized Avatars: Over 3,700 companies applied to a16z’s SPEEDRUN. In this episode, we meet the founders pushing the boundaries of what games can be. From the fusion of traditional gaming elements with modern tech-twists, a16z General Partner Andrew Chen and Partner Josh Lu discuss the challenges and wins of creating games that are not only fun but also integrate seamlessly into the digital age, from AI-twins to games that “move at the speed of culture”. Whether you’re a developer, an enthusiast, or just curious about the future of interactive entertainment, this episode provides a glimpse into how today's creators use creativity and technology to captivate. by a16z Podcast

31 min listen

Why America Must Lead in AI Investment with Senator Young (R-IN): Senator Todd Young (R-IN) speaks with a16z General Partner Martin Casado about the importance of open innovation and American leadership in AI, and why we need to support AI research at all levels — from the classroom to the war room. In this episode, we distinguish science fiction from science reality in the ever-evolving AI landscape. by a16z Podcast

25 min listen

Game On: Marc Andreessen & Andrew Chen Talk Creative Computers: The gaming industry stands as a pioneer of cutting-edge technologies, ushering in innovations like GPUs, virtual and augmented reality, physics engines, and immersive multiplayer experiences. In this episode, a16z cofounder Marc Andreessen and Andrew Chen, General Partner at a16z Games, dig into why a16z was compelled to establish a dedicated games fund. They explore the origins of tech pessimism, effective engagement with government in tech, its significance for the gaming community, the ongoing AI revolution, and even what Marc himself would build today if he didn't have his hands full. Recorded as part of a16z's extensive games fund accelerator, SPEEDRUN, this session offers valuable insights for founders and innovators at the intersection of games and technology. If you're passionate about shaping the future of gaming, consider applying for SPEEDRUN 3.0 at a16z.com/speedrun3. by a16z Podcast

41 min listen

Inside the Department of Defense and its Vision for the Future: From air-defining radar and electronic systems that helped the Allies win World War II, the origins of Silicon Valley are deeply rooted in government and defense. In today's episode, we get the chance to revisit that relationship with the United States Deputy Secretary of Defense, Kathleen Hicks. Deputy Secretary Hicks has spent decades of her career focused on defense policy and in her keynote address from a16z's second annual American Dynamism Summit in Washington, D.C., you'll get an inside look into the priorities of the DoD and how it views its past, present, and future. In the second half of the episode, you’ll hear highlights from Deputy Secretary Hicks' fireside chat with Wall Street Journal’s National Security Editor, Sharon Weinberger, where they dive into the numerous issues facing our country today, from Ukraine to the use of AI on the battlefield. by a16z Podcast

30 min listen

Politics & the Future of Tech with Marc Andreessen and Ben Horowitz: “If America is going to be America in the next one hundred years, we have to get this right.” - Ben Horowitz This week on “The Ben & Marc Show”, a16z co-founders Ben Horowitz and Marc Andreessen take on one of the most hot button issues facing technology today: tech regulation and policy. In this one-on-one conversation, Ben and Marc delve into why the political interests of “Big Tech” conflict with a positive technological future, the necessity of decentralized AI, and how the future of American innovation is at its most critical point. They also answer YOUR questions from X (formerly Twitter). That and much more. Enjoy! by a16z Podcast

103 min listen

The Real Price of Healthcare with Mark Cuban: From judging inventions on “Shark Tank” to reshaping the image of NBA ownership, Mark Cuban is known for many things. In this chat with a16z General Partner David Ulevitch, he discusses the importance of entrepreneurship for maintaining America’s status as the most innovative place on the planet. This includes making big bets, like he’s doing with Cost Plus Drugs, his latest venture that seeks to upend the prescription drug markets. by a16z Podcast

26 min listen

Devoting Your Life to Reinventing a Broken System: At the a16z LP Summit, we brought hundreds of our limited partners and portfolio founders together in Las Vegas. The event was truly overflowing with stories of how founders are challenging the status quo and harnessing technology to make the world a better place. Amidst these stories, it became clear that in the realms of public safety and healthcare, the stakes couldn't be higher—these sectors not only hold lives in balance but also stand as fertile ground for technological breakthroughs. In this episode, a16z General Partner Vijay Pande chats with Ed and Todd Park, the visionary siblings behind Devoted Health. Their mission? To overhaul a healthcare system they describe as critically essential yet deeply flawed. The Park brothers delve into the genesis of their ambition to construct a healthcare system from scratch, underscoring the sector's urgent need for technological innovation and the game-changing role of AI. Kicking off wi by a16z Podcast

25 min listen

Bringing AI to the Masses with Adam D’Angelo: Generative AI has initiated a transformative shift, reshaping our world in unprecedented ways. In a16z's AI Revolution series, we engage some of the most impactful builders in the field of AI discussing and debating where we are, where we’re going, and the big open questions in AI. In this episode, General Partner David George chats with Adam D'Angelo, the CEO and founder of Quora, wade into this fast-moving AI landscape, and specifically touch on how building infrastructure for creators can democratize AI. Adam, who is now building AI aggregator Poe and is on the board of OpenAI, has long been paying attention to this AI wave. He recounts this evolving fascination, and together Adam and David explore the dynamic synergy between humans and AI, highlighting the critical role of experimentation for founders in the AI realm. As a reminder, this conversation comes from our AI Revolution series, which you can dive into more deeply at a16z.co by a16z Podcast

28 min listen

A Nuclear Comeback: Are New Reactors the Answer?: Nuclear energy accounts for 20% of the electricity in the United States, but remarkably, 2023 marked the commissioning of the U.S.'s first new nuclear reactor in over three decades. The past few years have been a story of changing public opinion, but equally, innovative startups crafting groundbreaking reactor designs and an ambitious announcement by the U.S. government to triple nuclear power production by 2050. In this episode recorded at a16z’s American Dynamism Summit in Washington DC, a16z podcast host Steph Smith is joined by a16z General Partner David Ulevich, Doug Bernauer – CEO of microreactor company Radiant – and Dr. Kathryn Huff, Assistant Secretary of the Office of Nuclear Energy. From energizing the country's data centers to propelling the electric vehicles on our roads or powering the factories crafting tomorrow's innovations, they discuss why expanding our nuclear capacity is a national imperative. Stay tuned for mor by a16z Podcast

48 min listen

Intelligence in the Age of AI with new CTO of the CIA: Artificial intelligence has taken the world by storm. But despite the hype around personalized avatars or podcast language translation, artificial intelligence is not only impacting the creative spheres; in fact it’s hard to find an industry that isn’t being touched by this technology – and defense of our country is far from excluded. In this episode, originally recorded in the heart of Washington DC his January during a16z’s American Dynamism Summit, a16z General Partner Martin Casado and a16z enterprise editor. Derrick Harris are joined by the first-ever CTO of the CIA, Nand Mulchandani. In this wide-ranging conversation, they discuss the evolving relationship between analysts and AI, how governments can keep up with this exponential technology, and finally, how it’s impacting both offense and defense. This episode is essential listening for anyone interested in the intersection of technology, national security, and policy-m by a16z Podcast

47 min listen

From Silicon Valley to the Pentagon: The Future of Defense Innovation: The last few decades have been a period of transition for defense. An increasing number of startups have begun to rival large defense primes, the industry has gradually become a calculus of both hardware and software, and exponential technologies have forced the DoD to rethink how it has traditionally done business. These changing conditions were some of the inputs to resulting in the DIU – Defense Innovation Unit – starting in 2015 within the Department of Defense, focused on accelerating the adoption of technology. In this episode recorded at a16z’s American Dynamism Summit in January, a16z General Partner Katherine Boyle is joined by the Director of the DIU, Doug Beck, plus two critical founders ushering in this new era of defense: Brian Schimpf, cofounder and CEO of Anduril and Brandon Tseng, cofounder of Shield AI. So what does the next wave of defense innovation really look like? Let’s find out. by a16z Podcast

44 min listen

What is American Dynamism?: American Dynamism. A term coined by a16z General Partner, Katherine Boyle, two years ago, when she and David Ulevitch founded the firm's American Dynamism investing practice. Beyond a sector or movement, American Dynamism embodies innovation, community, and a unique philosophy touching every facet of American life. In this episode, we hear from 10 voices, including policymakers, founders, and funders, as they share what American Dynamism means to them. They discuss the critical technologies shaping the future and the challenges on the path to the next decade of dynamism. Stay tuned for more exclusive conversations from a16z's second annual American Dynamism Summit in Washington, D.C. by a16z Podcast

31 min listen

The Quest for True Signal: How Zynga Spotted Mobile: You might recognize the name Mark Pincus but we almost guarantee you recognize the game Farmville. Mark Pincus is the founder and longtime CEO of Zynga, known for its massive global franchise of games, including those household names like Farmville and Words with Friends. Zynga was also at the forefront of the transition to mobile and the use of large platforms like Facebook for distribution. In this episode Mark joins Josh Lu from the a16z Games team for a fireside chat. They discuss navigating major tech waves and recognizing "true signal" opportunities, and explore a wide range of topics, from the strategic insights that propelled Zynga to success, the future of the Metaverse, and the philosophy behind minimum viable products. This conversation offers invaluable insights for both gaming industry insiders and enthusiasts looking to understand the dynamics of tech innovation and entrepreneurship. by a16z Podcast

48 min listen

Beyond Uncanny Valley: Breaking Down Sora: In this episode of the a16z Podcast, a16z General Partner Anjney Midha connects with Stefano Ermon, Professor of Computer Science at Stanford and key figure at the lab behind the diffusion models now used in Sora, ChatGPT, and Midjourney. Together, they delve into the challenges of video generation, the cutting-edge mechanics of Sora, and what this all could mean for the road ahead. by a16z Podcast

35 min listen

Fraying Wires: The Decentralization of the Electric Grid: The electric grid needs an update. In this explainer, a16z Partner Ryan McEntush discusses the escalating complexity of the grid, unveils its vulnerabilities, and traces the evolutionary path that has led us to this point. From the surging demands of AI to outdated infrastructure, we delve into the potential roles of cutting-edge technologies such as solar batteries, natural gas, and nuclear power in shaping the grid's future. by a16z Podcast

43 min listen

Fixing Higher Education & New Startup Opportunities with Marc and Ben: "The Ben & Marc Show" features a16z's co-founders Ben Horowitz & Marc Andreessen. In this episode, Marc and Ben continue their in-depth exploration of the current education system. While Part I of their discussion unpacked the crisis facing higher education, Part II presents solutions to overhaul the modern university.In this one-on-one conversation, Ben and Marc delve into actions that existing institutions can take to improve their current and future situations. This includes exploring new methods for talent recruitment, providing a more individualized education experience for students, and reducing administrative bloat. They also apply an entrepreneurial lens to each university function, revealing startup opportunities poised to emerge – including the building of brand new institutions, nonprofits, and research entities. Enjoy! by a16z Podcast

120 min listen

Read Write Own: A new era: Chris Dixon is the founder and managing partner of a16z crypto and author of the new book Read Write Own: Building the Next Era of the Internet. Robert Hackett is an editor at a16z crypto who worked closely with him on the book as an editing and thought partner. They discuss the writing process, the book's themes, and what could follow the internet's read-write-own era. by a16z Podcast

80 min listen

The What, Who, and When with IPOs: In 2022 and 2023, US IPOs hit decade lows after the record high of 2021. Now, in 2024, will the IPO window reopen? In this episode, we revisit a conversation with Jeff Jordan, former CEO of OpenTable, and J.D. Moriarty, the former Head Managing Director and Head of Equity Capital Markets at Bank of America Merrill Lynch. Joined by Sonal Choksi, the pair takes you behind the scenes to unravel the complexities surrounding IPOs, including pricing, allocations, and the elusive "pop." They also discuss OpenTable’s IPO, which occurred immediately following the worst financial crisis since the Great Depression, and weigh in on the question: Can you time an IPO in an unpredictable year? by a16z Podcast

34 min listen

Jobs of the Future: In a world where technology is moving at an unprecedented pace, what will the jobs of the future look like? Kai Roemmelt, CEO of the online learning platform Udacity, and Lisa Gevelber, a key figure at Google responsible for building the Grow with Google program, unpack the seismic changes reshaping the tech and education realms. From disrupting hiring norms to redefining how we acquire degrees and engage globally, this episode poses the question: How can you skillfully navigate the challenges and seize the opportunities awaiting in this evolving landscape? by a16z Podcast

41 min listen

Introducing Raising Health: Fireside Chat with Sean Duffy: Big news from a16z: Bio Eats World, our sibling show from a16z Bio+Health, is now Raising Health! We’re excited to share Raising Health’s first episode here where Sean Duffy, cofounder and CEO of Omada Health, joins Vijay Pande, founding general partner of Bio + Health. Sean and Vijay discuss the building and growth of Omada, from the early days to now. As the cofounder of one of the original digital health companies, Sean has unique insight into the growth of both the digital health field and the changing venture capital environment. They also talk about the future of AI, how Omada is leveraging AI, and the challenges that might arise with using a technology in a caregiving environment. You can listen to more episodes of Raising Health here: https://link.chtbl.com/IqBoJ2By?sid=a16z11824 by a16z Podcast

35 min listen

Crisis in Higher Ed & Why Universities Still Matter with Marc & Ben: In this one-on-one conversation, Marc and Ben tackle the university system – what has certainly been a hot topic that’s been dominating the news over the past few months. As Marc states at the top of the episode, universities matter tremendously to our world, but they’re currently in a state of crisis. Together, Ben and Marc take a “structural” look at higher education, delving deep into the twelve functions of the modern university. They also unpack the numerous challenges that universities face today – student debt and the replication crisis, among them. They also discuss topics including DEI, student athlete admissions, accreditation, inflation, and much more. As colleges face an existential threat that could have long lasting repercussions, how can we find ways to improve these institutions, while being open to new entrepreneurial opportunities in education? by a16z Podcast

108 min listen

Drones, Data, and Deterrence: Technology's Role in Public Safety: Flock is a public safety technology platform that operates in over 4,000 cities across the United States, and solves about 2,200 crimes daily. That’s 10 percent of reported crimes nationwide. Taken from a16z’s recent LP Summit, a16z General Partner David Ulovich joins forces with Flock Safety’s founder, Garrett Langley and Sheriff Kevin McMayhill of the Las Vegas Metropolitan Police Department. Together, they cover the delicate balance between using technology to combat crime and respecting individual privacy, and explore the use of drones and facial recognition, building trust within communities, and the essence of objective policing. by a16z Podcast

34 min listen

DNA's Potential to Store the World's Data: Nature’s blueprint – DNA – is an incredibly efficient machine. You cannot see it with the naked eye, yet it can last for hundreds, maybe even millions of years. Plus, the storage capacity of a single gram of DNA is over 200 million gigabytes! As the cost of DNA sequencing (reading) and synthesis (writing) comes down, scientists are looking to our very own biology for applications reaching as far as data storage. Learn more about this fascinating world with a16z General Partner Vijay Pande, as he says, this next wave of biological computing will “be the mother of many new exponentials to come.” by a16z Podcast

21 min listen

Best of 2023: From AI to Healthcare to Housing: As we close off 2023, we wanted to revisit some of our favorite episodes from the last year. From AI hardware, to healthcare regulation, to disrupting the world’s largest asset class, to the electrification of nearly everything… there’s something in here for all listeners. by a16z Podcast

60 min listen

The Future of Longevity with Tony Robbins: Marc and Ben are joined by special guest Tony Robbins to discuss new breakthroughs in regenerative medicine, AI, biohacking, gene editing, mindset and why this might be the best time to be alive. by a16z Podcast

82 min listen

2024 Big Ideas: Developer Influence, Maritime Upgrades, and New Video Intelligence: A new age of maritime exploration, the rise of the developer as a buyer in financial services, and more applications for computer vision and video intelligence. We asked over 40 partners across a16z to preview one big idea they believe will drive innovation in 2024. Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved? by a16z Podcast

47 min listen

Text to Video: The Next Leap in AI Generation: General Partner Anjney Midha explores the cutting-edge world of text-to-video AI with AI researchers Andreas Blattman and Robin Rombach. Released in November, Stable Video Diffusion is their latest open-source generative video model, overcoming challenges in size and dynamic representation. In this episode Robin and Andreas share why translating text to video is complex, the key role of datasets, current applications, and the future of video editing. by a16z Podcast

33 min listen

2024 Big Ideas: Voice-First Apps, AI Moats, Never-Ending Games, and Anime Takes Off: Voice-First Apps, AI Moats, Never-Ending Games, and Anime. We asked over 40 partners across a16z to preview one big idea they believe will drive innovation in 2024. Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved? by a16z Podcast

61 min listen

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2024 Big Ideas: Miracle Drugs, Programmable Medicine, and AI Interpretability

2024 Big Ideas: Miracle Drugs, Programmable Medicine, and AI Interpretability

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