With ever-evolving technologies, cancer treatments will almost certainly become more effective and less invasive in the future. A new procedure that will likely play an important role in the future of interventional oncology is histotripsy. While the procedure could be adopted by a variety of specialties, we believe that interventional oncologists are well-positioned and best equipped to lead the introduction and clinical translation of this new technology.In the audio version of "Breaking down histotripsy: Inside a new ablation modality with cancer applications"  (Fall 2021 IR Quarterly, pp. 12-14), authors Fred T. Lee, MD, Timothy J. Ziemlewicz, MD, Zhen Xu, PhD, and Paul Laeseke MD, PhD, describe the potential for histotripsy in cancer treatment and the critical role interventional oncologists will play. Read the article. Contact us with your ideas and questions, or read more about about interventional radiology in IR Quarterly magazine or SIR's Patient Center.(c) Society of Interventional Radiology.Support the show