Multiple studies demonstrate that fever/elevated temperature is associated with poor outcomes in patients with vascular brain injury; however, there are no conclusive studies that demonstrate that fever prevention/controlled normothermia is associated with better outcomes. The primary objective of the INTREPID (Impact of Fever Prevention in Brain-Injured Patients) trial was to test the hypothesis that fever prevention is superior to standard temperature management in patients with acute vascular brain injury. Dr David Greer, Professor and Chair of the Department of Neurology at Boston University School of Medicine, joins Dr Nick Morris to discuss the results from the study, which have just been released.