20 min listen
Therapeutic effect of dietary interventions on senescence in animals and humans: A systematic review
Therapeutic effect of dietary interventions on senescence in animals and humans: A systematic review
ratings:
Length:
20 minutes
Released:
Aug 1, 2023
Format:
Podcast episode
Description
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.07.28.550928v1?rss=1
Authors: Guan, L., Eisenmenger, A., Crasta, K., Sandalova, E., Maier, A. B.
Abstract:
Cellular senescence is a permanent state of cell arrest, regarded as a therapeutic target for ageing and age-related diseases. Natural products hold the translational potential to promote healthy ageing. This systematic review examined dietary interventions and association with senescence in animals and humans to identify senotherapeutic potential. The databases PubMed and Embase were systematically searched. 82 articles consisting of 78 animal studies and 4 human studies aimed to reduce cellular senescence load using dietary interventions. In animal studies, the most-frequently used senescence model was normal ageing (26 studies), followed by D-galactose-induced models (17 studies). Resveratrol (8 studies), vitamin E (4 studies) and soy protein isolate (3 studies) showed positive effects on reducing the level of senescence markers such as p53, p21, p16 and senescence-associated beta-galactosidase in various tissues of physiological systems. Ginsenoside Rg1 had no positive effect on reducing senescence in human muscle tissues after exercise. Resveratrol, vitamin E and soy protein isolate are promising senotherapeutics studied in animals. Studies testing dietary interventions with senotherapeutic potential in humans are limited and translation is highly warranted.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
http://biorxiv.org/cgi/content/short/2023.07.28.550928v1?rss=1
Authors: Guan, L., Eisenmenger, A., Crasta, K., Sandalova, E., Maier, A. B.
Abstract:
Cellular senescence is a permanent state of cell arrest, regarded as a therapeutic target for ageing and age-related diseases. Natural products hold the translational potential to promote healthy ageing. This systematic review examined dietary interventions and association with senescence in animals and humans to identify senotherapeutic potential. The databases PubMed and Embase were systematically searched. 82 articles consisting of 78 animal studies and 4 human studies aimed to reduce cellular senescence load using dietary interventions. In animal studies, the most-frequently used senescence model was normal ageing (26 studies), followed by D-galactose-induced models (17 studies). Resveratrol (8 studies), vitamin E (4 studies) and soy protein isolate (3 studies) showed positive effects on reducing the level of senescence markers such as p53, p21, p16 and senescence-associated beta-galactosidase in various tissues of physiological systems. Ginsenoside Rg1 had no positive effect on reducing senescence in human muscle tissues after exercise. Resveratrol, vitamin E and soy protein isolate are promising senotherapeutics studied in animals. Studies testing dietary interventions with senotherapeutic potential in humans are limited and translation is highly warranted.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
Released:
Aug 1, 2023
Format:
Podcast episode
Titles in the series (100)
Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA by PaperPlayer biorxiv cell biology