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Self-extinguishing relay waves enable homeostaticcontrol of human neutrophil swarming
Self-extinguishing relay waves enable homeostaticcontrol of human neutrophil swarming
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Length:
20 minutes
Released:
Jun 28, 2023
Format:
Podcast episode
Description
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.06.27.546744v1?rss=1
Authors: Strickland, J., Pan, D., Godfrey, C., Kim, J. S., Hopke, A., Degrange, M., Villavicencio, B., Mansour, M. K., Zerbe, C. S., Irimia, D., Amir, A., Weiner, O. D.
Abstract:
Neutrophils exhibit self-amplified swarming to sites of injury and infection. How swarming is controlled to ensure the proper level of neutrophil recruitment is unknown. Using an ex vivo model of infection, we find that human neutrophils use active relay to generate multiple pulsatile waves of swarming signals. Unlike classic active relay systems such as action potentials, neutrophil swarming relay waves are self-extinguishing, limiting the spatial range of cell recruitment. We identify an NADPH-oxidase-based negative feedback loop that is needed for this self-extinguishing behavior. Through this circuit, neutrophils adjust the number and size of swarming waves for homeostatic levels of cell recruitment over a wide range of initial cell densities. We link a broken homeostat to neutrophil over-recruitment in the context of human chronic granulomatous disease.
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Podcast created by Paper Player, LLC
http://biorxiv.org/cgi/content/short/2023.06.27.546744v1?rss=1
Authors: Strickland, J., Pan, D., Godfrey, C., Kim, J. S., Hopke, A., Degrange, M., Villavicencio, B., Mansour, M. K., Zerbe, C. S., Irimia, D., Amir, A., Weiner, O. D.
Abstract:
Neutrophils exhibit self-amplified swarming to sites of injury and infection. How swarming is controlled to ensure the proper level of neutrophil recruitment is unknown. Using an ex vivo model of infection, we find that human neutrophils use active relay to generate multiple pulsatile waves of swarming signals. Unlike classic active relay systems such as action potentials, neutrophil swarming relay waves are self-extinguishing, limiting the spatial range of cell recruitment. We identify an NADPH-oxidase-based negative feedback loop that is needed for this self-extinguishing behavior. Through this circuit, neutrophils adjust the number and size of swarming waves for homeostatic levels of cell recruitment over a wide range of initial cell densities. We link a broken homeostat to neutrophil over-recruitment in the context of human chronic granulomatous disease.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
Released:
Jun 28, 2023
Format:
Podcast episode
Titles in the series (100)
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