Benzi Kluger (University of Rochester Medical Center, Rochester, NY, USA), Claire Creutzfeldt (University of Washington, Seattle, WA, USA), and Malenna Sumrall (University of Colorado Anschutz Medical Campus, Aurora, CO, USA) join Jonathan Blott to discuss palliative care for individuals with neurological diseases, exploring the challenges and opportunities in enhancing the quality of life for those affected by neurological conditions. Their Review is published in the July issue of The Lancet Neurology.