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‘Pangenome’ aims to capture the breadth of human diversity

‘Pangenome’ aims to capture the breadth of human diversity

FromNature Podcast


‘Pangenome’ aims to capture the breadth of human diversity

FromNature Podcast

ratings:
Length:
21 minutes
Released:
May 10, 2023
Format:
Podcast episode

Description

In this episode:00:45 Making a more diverse human genomeThe first draft of the human genome ushered in a new era of genetics research. Since its publication, researchers have constructed ever more accurate ‘reference genomes’ – baselines against which others are compared. But these are based on the DNA of a small number of people, and don’t represent the genetic variation known to exist across human populations. To address this, a consortium of researchers have published the first draft of a ‘pangenome’, which combines the genomes of 47 genetically diverse individuals. This draft provides a more complete picture of the human genome, and is the starting point for a project that aims to include sequences from 350 individuals.Research article: Liao et al. Research article: Vollger et al.Research article: Guarracino et al.News and Views Forum: Human pangenome supports analysis of complex genomic regions08:33 Research HighlightsA wearable sensor that lets users see infrared light, and how a vulture’s culture can influence its dining habits.Research Highlight: Wearable sensor gives a glimpse of ‘invisible’ lightResearch Highlight: What drives a scavenger’s diet? Vulture culture11:06 Briefing ChatWe discuss some highlights from the Nature Briefing. This time, a new phosphate-storing organelle found in fruit fly cells, and how extracted DNA revealed who held a deer-tooth pendant 20,000 years ago.Nature News: New cellular ‘organelle’ discovered inside fruit-fly intestinesNature News: Prehistoric pendant’s DNA reveals the person who held itSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.
Released:
May 10, 2023
Format:
Podcast episode

Titles in the series (100)

The Nature Podcast brings you the best stories from the world of science each week. We cover everything from astronomy to zoology, highlighting the most exciting research from each issue of Nature journal. We meet the scientists behind the results and providing in-depth analysis from Nature's journalists and editors.