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Recent developments in the production of 2D- and 3D colon and stomach adenocarcinomas primary cell models
Recent developments in the production of 2D- and 3D colon and stomach adenocarcinomas primary cell models
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Length:
20 minutes
Released:
Feb 26, 2023
Format:
Podcast episode
Description
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.02.26.529716v1?rss=1
Authors: Tokarchuck, I. M., Mushii, O., Dreus, A., Koziaruk, A. A., Shapochka, D. O., Ryzhak, O. A., Venhryk, S. O., Golovko, I. S., Ryabuhin, S. V., Hanopolskyi, A. I., Judd, D. B., Volochnyuk, D. M.
Abstract:
Gastric and colorectal cancer models are essential for the advancement of precision medicine discovery and development. 2D attached monolayer, spheroid and organoid approaches have all been used in the formation of biobanks containing primary patient-derived cells. Here, we report an assessment of those procedures for a panel of nine patient-derived adenocarcinoma samples, along with the most applicable method for the bio-banking of these cell types. A live cell biobank of tumour specimens would facilitate drug discovery laboratories to evaluate drugs on the population of cell cultures, prior to the clinical phase.
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http://biorxiv.org/cgi/content/short/2023.02.26.529716v1?rss=1
Authors: Tokarchuck, I. M., Mushii, O., Dreus, A., Koziaruk, A. A., Shapochka, D. O., Ryzhak, O. A., Venhryk, S. O., Golovko, I. S., Ryabuhin, S. V., Hanopolskyi, A. I., Judd, D. B., Volochnyuk, D. M.
Abstract:
Gastric and colorectal cancer models are essential for the advancement of precision medicine discovery and development. 2D attached monolayer, spheroid and organoid approaches have all been used in the formation of biobanks containing primary patient-derived cells. Here, we report an assessment of those procedures for a panel of nine patient-derived adenocarcinoma samples, along with the most applicable method for the bio-banking of these cell types. A live cell biobank of tumour specimens would facilitate drug discovery laboratories to evaluate drugs on the population of cell cultures, prior to the clinical phase.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
Released:
Feb 26, 2023
Format:
Podcast episode
Titles in the series (100)
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