A Treat Locally, Act Globally Strategy for Treating Cancer

Boosting the Power of Dendritic Cancer Vaccines: The idea of developing cancer vaccines that harness dendritic cells is not new, but Diakonos Oncology thinks it’s been able to solve the lack of efficacy that has plagued this approach. The company combines its vaccines with RNA and proteins from a p... by The Bio Report

19 min listen

Overcoming Resistance in Cancer with Chemistry: Kinase inhibitors have given rise to an era of precision medicine for the treatment of cancer, but the ability of cancer cells to mutate enables tumors to develop resistance to existing therapies. Nuvalent is developing therapies that both target the... by The Bio Report

30 min listen

Teaching an Old Drug a New Trick to Prevent Lyme Disease: Each year, an estimated 400,000 people in the United States will be diagnosed with Lyme disease, a billion-dollar healthcare problem caused by a bacterial infection that is transmitted through the bite of a tick. The condition can cause joint pain an... by The Bio Report

20 min listen

A New Class of Cell Therapies to Target Solid Tumors: In February, the U.S. Food and Drug Administration approved the first tumor-infiltrating lymphocyte, or TIL therapy, for solid tumors. The approval was hailed as a milestone that points the path forward for a new class of cell therapies for solid tum... by The Bio Report

33 min listen

Targeting the Tumor Microenvironment with Lipid-Based Immunotherapies: Lipids have long been used as drug delivery vehicles, but HighField Biopharmaceutics is repurposing lipids as drugs to fight cancer. The company’s technology platform is seeking to change the immunotherapy landscape with new treatments that are bette... by The Bio Report

35 min listen

A Company Born from a Father Who Wore His Heart on His Sleeve: Jeremiah Robison’s daughter Sofia was born with cerebral palsy, a congenital movement disorder. Watching her physicians use body monitors to measure her gait, and later apply functional electrical stimulation as physical therapy, gave him an idea to ... by The Bio Report

32 min listen

Using AI to Improve Burn Care: Physicians treating people with burns typically incorrectly assess the depth of burn wounds in about 25 to 30 percent of cases. That, in part, is due to a lack of diagnostic tools to assess the severity of a burn and to determine the best approach to... by The Bio Report

24 min listen

A Home for Biotech in the City that Never Sleeps: New York City is not the first place that comes to mind when thinking of biotech clusters, but the Big Apple has been a growing center of biomedical innovation with its mix of academic research hospitals, finance, and growing number of biopharmaceuti... by The Bio Report

33 min listen

Biopharma R&D Growing Stronger: Funding levels, drug launches, and R&D success rates all grew in 2023, according to a new report from the IQVIA Institute for Human Data Science. Global funding of biopharmaceutical research and development increased to $72 billion, up from $61 b... by The Bio Report

31 min listen

The Benefits of Having a Multitude of Cins: In January 2023, AstraZeneca agreed to acquire CinCor Pharma, the CinRx cardio-renal disease therapy subsidiary, for $1.3 billion. The deal included a potential additional $500 million milestone payment. The price represented a 121 percent premium to... by The Bio Report

33 min listen

Making ADCs Smarter and Safer with a Simple Twist of Fate: Antibody-drug conjugates can deliver chemotherapy directly to tumors but more than 95 percent of the dose often ends up in healthy tissues, decreasing efficacy and increasing toxicity. Mythic Therapeutics FateControl technology improves the uptake of... by The Bio Report

24 min listen

Targeting a Natural Repair System to Restore Brain Health: The HGF/MET neurotrophic system plays a critical role in the maintenance and repair of connections in the brain. Enhanced signaling along this pathway has the potential to reduce inflammation, slow neurodegeneration, and provide neuroprotection. Athi... by The Bio Report

19 min listen

Programing Cells in a Predictable and Scalable Way: The advent of induced pluripotent stem cells, cells that can be coaxed into becoming virtually any type of cell within the body, promised to usher in a new era of regenerative medicine and improved drug discovery. In practice, though, the ability to ... by The Bio Report

32 min listen

Why DNA May Be the Data Storage Medium of the Future: Some 100 trillion gigabytes of data are created and consumed each year, an amount that is expected to double by 2025. The demand for data storage carries the need for significant physical space and power requirements in the form of digital data cente... by The Bio Report

32 min listen

Scouring Genetic Variation within Our Cells for Drug Targets: People tend to think of each person having their own unique genome. Quotient Therapeutics is taking an approach to drug discovery based on the reality that from cell to cell within a given individual, there can be trillions of divergent genomes. Chan... by The Bio Report

26 min listen

Correcting Gene Dysregulation to Treat Diseases: Regardless of the cause of a disease, most diseases involve gene dysregulation. Omega Therapeutics is developing a new class of programmable, epigenomic, mRNA medicines designed to make specific epigenetic changes and correct abnormal gene expression... by The Bio Report

45 min listen

Using Technology to Regain Abilities after Spinal Cord Injury: The effects of spinal cord injury extend beyond the loss of mobility. They can include a toll on mental health, a feeling of exclusion, and a general decline in the quality of life as a result of being able to stand and interact eye-to-eye with other... by The Bio Report

25 min listen

Why Drug Developers Have a Growing Interest in Targeting Mitochondria: Mitochondria are often referred to as the “powerhouses” of the cell, but as scientists gain a greater understanding of these essential organelles, they are coming to discover they play a more expansive role in health and disease. The Foundation for t... by The Bio Report

39 min listen

Beefing Up Computational Muscle to Understand Molecular Activity of Drug Candidates: Sandbox AQ, the Alphabet spin-out backed with $500 million in investment, in June 2023 unveiled it AQBioSim division. The division is working to bring SandoxAQ’s AI and quantum-inspired computing to develop new treatments for intractable medical cond... by The Bio Report

32 min listen

Targeting a Multitude of CIN in Cancer Cells: It’s long been understood that chromosomal instability (CIN) is a characteristic of cancer cells, but it also represents a key difference between cancer cells and healthy cells that can be exploited. Volastra is developing medicines for a wide range ... by The Bio Report

21 min listen

The Year in Biotech and What’s Ahead in 2024: Though the year began with a banking crisis and has been marked with layoffs and restructurings, we have managed to avoid a feared recession. It’s been a big year for new drug approvals, M&A activity has been brisk, and biotech stocks have rallie... by The Bio Report

33 min listen

Transforming Healthcare with Data: Vik Bajaj has long lived at the intersection of physical sciences, engineering, data science, and the life sciences—first as an academic working to improve diagnostic imaging at Stanford University and later as a chief scientific officer at GRAIL and... by The Bio Report

51 min listen

Realizing the Promise of IL-2 Therapies with AI: Interleukin-2 therapies have been seen as promising ways to treat solid tumors, but they have proven challenging because of the ability of IL-2 to both activate and suppress the immune system. Their effectiveness has been limited because of potential... by The Bio Report

23 min listen

Unlocking Real-World Data to Improve Outcomes: Real-world data promises to provide insights that lead to better therapies, change how we treat diseases, and improve outcomes for patients. One of the limits of realizing benefits from all of the health information we are swimming in is the lack of ... by The Bio Report

40 min listen

A Silicon Valley Entrepreneur Investing at the Intersection of Tech and Biotech: Artificial intelligence promises to reshape the healthcare landscape and deliver new insights into the molecular drivers of health and wellness, provide rapid diagnoses of patients, and discover and design therapies that extend beyond human imaginati... by The Bio Report

25 min listen

A Company Betting Its Physics-Based AI Will Fuel a Quantum Leap in Drug Discovery: Though many drug developers are harnessing AI to create novel chemical compounds, Iambic Therapeutic’s generative AI is leveraging quantum mechanics to get to better drugs. It says its physics-informed machine learning approach has yielded promising ... by The Bio Report

24 min listen

Detecting Alzheimer’s Disease Early through a Blood Test: One of the challenges with treating Alzheimer’s disease is diagnosing patients early enough in the course of its progression to have a meaningful impact with treatments. Sunbird Bio said it can accurately detect and differentiate specific proteins th... by The Bio Report

25 min listen

Addressing Supply-Chain Challenges Underlying Drug Shortages with Synthetic Biology: About 40 percent of all drugs in the Western world are derived from plants. But challenges with producing a reliable supply inherent with materials derived from agricultural processes can lead to drug shortages as climate events, pests, and plant dis... by The Bio Report

28 min listen

Building Better and More Affordable Vaccines: The COVID 19 pandemic provided a painful reminder of the global need to protect people against the threat of existing and emerging infectious diseases. Emergex Vaccines is developing fully synthetic vaccines that provide advantages over live attenuat... by The Bio Report

42 min listen

Overcoming Resistance to Targeted Therapies: The advent of targeted therapies has contributed to notable progress in the fight against cancer, but the ability of cancers to develop resistance to these precision medicines continues to leave patients in need of new approaches. Concarlo Therapeuti... by The Bio Report

30 min listen

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A Treat Locally, Act Globally Strategy for Treating Cancer

A Treat Locally, Act Globally Strategy for Treating Cancer

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