Continuing education episode! In the remote history of transfusion medicine, life was simple. We had exactly one product: Whole blood. Things changed, and for the last 50 years or so, we began to separate whole blood into red cells, plasma, and platelets. As we learn more and more about what works and what doesn’t in trauma resuscitation, some are looking a return to whole blood. Dr. Mark Yazer is helping to lead that discussion, specifically to the use of low-titer group O cold-stored whole blood, which he calls “the ideal pre- and early in-hospital resuscitation fluid!” In this episode, Mark returns to outline his case for that outrageous statement! This episode is eligible for FREE CME and SAMs/CC credit for physicians and P.A.C.E. contact hours for laboratorians through Transfusion News Continuing Education on Wiley Health Learning.