Doug talks about the 49ers losing starting quarterback Jimmy Garoppolo for the rest of the season with a foot injury and wonders out loud if the 49ers will take a chance on Baker Mayfield, who was just put on waivers by the Panthers.  Doug gives his thoughts on Deion Sanders taking the Colorado job.  NFL Analyst John Middlekauff joins Doug to talk about the 49ers' quarterback situation, Deshaun Watson's debut with the Browns, and the other major headlines around the NFL. Plus, Dan Beyer takes Doug through a game of "Big Deal, Little Deal or No Deal?".See omnystudio.com/listener for privacy information.