Dr. Christen Shoesmith and Dr. Colleen O’Connell discuss the first Canadian guideline on the care and management of patients with amyotrophic lateral sclerosis (ALS). Dr. Shoesmith and Dr. O'Connell are two of the authors of the guideline, which is intended for ALS clinicians, allied health professionals and primary care providers and includes a patient-focused approach to care, with attention to holistic and emotional aspects of well-being.Dr. Christen Shoesmith is a neurologist and medical director of the Motor Neuron Disease Clinic at London Health Sciences Centre in London, Ontario. She is also chair of the ALS guidelines working group. Dr. Colleen O’Connell is a physical medicine and rehabilitation physician at the Stan Cassidy Rehabilitation Centre in Fredericton, New Brunswick.The clinical practice guideline is published in CMAJ: www.cmaj.ca/lookup/doi/10.1503/cmaj.191721Podcast transcript: https://www.cmaj.ca/transcript-191721Subscribe to CMAJ Podcasts on Apple Podcasts or your favourite podcast app. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.