Dr. Sean Wharton and Dr. David Lau discuss a newly published clinical practice guideline on obesity management. They are joined by Lisa Schaffer, who talks about her experience as a Canadian living with obesity. They discuss the complex interplay of factors that can lead to obesity, such as genetics, metabolic, behavioural, psychological and environmental factors. They also talk about stigma and its negative impact on health independent of other factors. Dr. Sean Wharton is an internist, associate professor and clinical researcher at McMaster University in Hamilton and York University in Toronto, Ontario. Dr. David Lau is an endocrinologist, researcher and professor of medicine, biochemistry and molecular biology at the University of Calgary Cumming School of Medicine. Lisa Schaffer is a patient-partner and chair of the public engagement committee with Obesity Canada.The clinical practice guideline is published in CMAJ: www.cmaj.ca/lookup/doi/10.1503/cmaj.191707Podcast transcript: https://www.cmaj.ca/transcript-191707-----------------------------------Subscribe to CMAJ Podcasts on Apple Podcasts or your favourite podcast app. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.