Dr. Gordon Guyatt discusses available evidence for many of the treatments being trialed in patients with COVID-19. He and his co-authors developed a clinical practice guideline that systematically reviewed and critically appraised direct and indirect evidence.Dr. Guyatt is a specialist in internal medicine and clinical epidemiologist at McMaster University in Hamilton, Ontario. He is also an officer of the Order of Canada for his ground-breaking work in evidence-based medicine.The guideline article he co-authored is published in CMAJ: www.cmaj.ca/lookup/doi/10.1503/cmaj.200648This guideline will be updated at https://app.magicapp.org/app#/guideline/EK6W0n as new evidence becomes available.CMAJ COVID-19 resource page: www.cmaj.ca/covid-19Podcast transcript: https://www.cmaj.ca/transcript-200648-----------------------------------Subscribe to CMAJ Podcasts on Apple Podcasts or your favourite podcast app. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.