In this interview, Dr. David Grimes and Dr. Tiago Mestre discuss diagnosis and management of Parkinson disease, including: how to first recognize it, progression, treatment (medications, deep brain stimulation, exercise), nonmotor features such as depression, and palliative care. Dr. Grimes and Dr. Mestre are two of the authors of a new Canadian clinical practice guideline published in the Canadian Medical Association Journal.Dr. David Grimes is chief of the division of neurology and director of the Parkinson Disease and Movement Disorder Clinic at The Ottawa Hospital. Dr. Tiago Mestre is a movement disorder neurologist and director of the Deep Brain Stimulation Program at The Ottawa Hospital.To read the clinical practice guideline: www.cmaj.ca/lookup/doi/10.1503/cmaj.181504-----------------------------------Subscribe to CMAJ Podcasts on Apple Podcasts, iTunes, Google Play, Stitcher, Overcast, Instacast, or your favourite aggregator. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.