In this interview, Dr. Darrell Tan takes listeners through the new Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis. He offers practical clinical guidance for front-line health workers.Dr. Darrell Tan is an infectious diseases physician and clinician–scientist at St. Michael’s Hospital in Toronto. He is also co-leader of the Biomedical HIV Prevention Working Group of the CIHR Canadian HIV Trials Network. He co-authored the HIV guideline published in CMAJ.Full guideline article: www.cmaj.ca/lookup/doi/10.1503/cmaj.170494Podcast transcript: https://www.cmaj.ca/transcript-170494Subscribe to CMAJ Podcasts on Apple Podcasts or your favourite podcast app. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.