Please support us on our Patreonhttps://www.patreon.com/anaesthesiaAll proceeds will go to Fund a Fellow to help train anaesthetists in developing countries whilst acknowledging the work it takes to keep creating this educational resource.Drug Choice⁃Describe toxicities that are specific to:⁃1) Drug Class⁃2) Individual DrugDrug Exposure Across Time (Dt)⁃Factors that increase (Dt) will increase the risk of toxicity. These will include:⁃1) Increased or Additive Dosing from the same class of drugs⁃2) Duration and Frequency of Exposure⁃3) Decreased Hepatic Clearance⁃4) Decreased Renal EliminationPatient Variabilities⁃For drugs that require hepatic metabolism⁃1) Neonates and patients with hepatic failure have decreased hepatic enzyme activity⁃2) Elderly and patients with cardiac failure have decreased cardiac output and decreased hepatic blood flow⁃For drugs that require renal elimination⁃1) Neonates and patients with renal failure have decrease renal blood flow⁃Pathological and Genetic factors may increase toxicityIf you enjoyed this content please like and subscribePlease post any comments or questions below. Check out www.anaesthesiacollective.com and sign up to the ABCs of Anaesthesia facebook group for other content.Any questions please email lahiruandstan@gmail.comDisclaimer: The information contained in this video/audio/graphic is for medical practitioner education only. It is not and will not be relevant for the general public.Where applicable patients have given written informed consent to the use of their images in video/photography and aware that it will be published online and visible by medical practitioners and the general public.This contains general information about medical conditions and treatments. The information is not advice and should not be treated as such. The medical information is provided “as is” without any representations or warranties, express or implied. The presenter makes no representations or warranties in relation to the medical information on this video. You must not rely on the information as an alternative to assessing and managing your patient with your treating team and consultant. You should seek your own advice from your medical practitioner in relation to any of the topics discussed in this episode’ Medical information can change rapidly, and the author/s make all reasonable attempts to provide accurate information at the time of filming. There is no guarantee that the information will be accurate at the time of viewingThe information provided is within the scope of a specialist anaesthetist (FANZCA) working in Australia.The information presented here does not represent the views of any hospital or ANZCA.These videos are solely for training and education of medical practitioners, and are not an advertisement. They were not sponsored and offer no discounts, gifts or other inducements. This disclaimer was created based on a Contractology template available at http://www.contractology.com.