Henry Nasrallah, MD, was the first-ever guest on the MDedge Psychcast. In a three-part series, he joined Lorenzo Norris, MD, host of the Psychcast and editor in chief of MDedge Psychiatry, to talk about schizophrenia. In this throwback episode, the three-part conversation has been edited together into one episode.  Part I: Etiology, presentation, and recent advances  Part II: Manifestations; treating early Part III: Treatment of first-episode schizophrenia In part I, Dr. Nasrallah and Dr. Norris talk about the etiology, presentation, and the recent advances in how schizophrenia is conceptualized. In part II, the two discuss the need for clinicians to treat the schizophrenia as early in the disease process as possible. In part III, the conversation continues, as they talk about treatment of a patient's first episode of schizophrenia.  Henry Narallah, MD, is Sydney W. Souers Endowed Chair and professor and chairman of psychiatry and behavioral sciences at Saint Louis University. He also is editor in chief of Current Psychiatry.  You can read some of Dr. Nasrallah's work in Current Psychiatry here.    For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgePsych