In this episode, we review the clinical presentation, history and physical examination as well as the ROME-IV diagnostic criteria for a diagnosis of IBS. We review the different subtypes of IBS as well as symptom management and emerging treatments for IBS. Our medicine minute focuses on the evidence supporting the use of eluxadoline in patients with IBS-D. Podcast written by: Dr. Nawid Sayed (Internal Medicine Resident)Reviewed by: Dr. David Rodrigues (Neurogastroenterology)  and Dr. Laura Marcotte (General Internist)Sound editing by: Dr. Alison LaiInfographic by Dr. Caitlyn VlasschaertSupport the show