Bret and Heather and Ivermectin.  Oh my. IDSG returns from it's 17 year absence with a banger of an episode in which Daniel dishes out THE FUCKING TEA on Bret Weinstein & Heather Heying (again) and their irresponsible spreading (in hushed, reasonable voices) of potentially lethal conspiracy theories and bad science re Covid, Wuhan, vaccines, and Ivermectin.  Content Warnings. Podcast Notes: Please consider donating to help us make the show and stay independent.  Patrons get exclusive access to one full extra episode a month. Daniel's Patreon: https://www.patreon.com/danielharper Jack's Patreon: https://www.patreon.com/user?u=4196618 IDSG Twitter: https://twitter.com/idsgpod Daniel's Twitter: @danieleharper Jack's Twitter: @_Jack_Graham_ IDSG on Apple Podcasts: https://podcasts.apple.com/us/podcast/i-dont-speak-german/id1449848509?ls=1 Show Notes: Bret Weinstein Odysee Bret interviews Yuri Deigin. Yuri Deigin, Lab Made? SARS-CoV-2 Geneaology Through the Lens of Gain of Function Research Indeed, virologists, including the leader of coronavirus research at the Wuhan Institute of Virology, Shi Zhengli, have done many similar things in the past — both replacing the RBM in one type of virus by an RBM from another, or adding a new furin site that can provide a species-specific coronavirus with an ability to start using the same receptor (e.g. ACE2) in other species. In fact, Shi Zhengli’s group was creating chimeric constructs as far back as 2007 and as recently as 2017, when they created a whole of 8 new chimeric coronaviruses with various RBMs. In 2019 such work was in full swing, as WIV was part of a $3.7 million NIH grant titled Understanding the Risk of Bat Coronavirus Emergence. Under its auspices, Shi Zhengli co-authored a 2019 paper that called for continued research into synthetic viruses and testing them in vitro and in vivo: Bret and Heather on Real Time with Bill Mahr on the Lab-Leak Hypothesis CLIP (Bret and Heather on BIll Maher Lab Leak) – starts at beginning of clip. Andersen, et al. The proximal origin of SARS-CoV-2 SARS-CoV-2 is the seventh coronavirus known to infect humans; SARS-CoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus. Garry, Robert. [Early appearance of two distinct genomic lineages of SARS-CoV-2 in different Wuhan wildlife markets suggests SARS-CoV-2 has a natural origin](https://virological.org/t/early-appearance-of-two-distinct-genomic-lineages-of-sars-cov-2-in-different-wuhan-wildlife-markets-suggests-sars-cov-2-has-a-natural-origin/691 This Week in Virology 762: SARS-Cov-2 origins with Robert Garry CLIP (Two Covid Lineages in Wuhan Market) – Starts about 39:00 in TWIV762 potholer54, Did SARS-Cov-2 start in a Chinese Lab? potholer54, More “man-made” SARS-CoV-2 lab-leak malarky Scott Gavura, Science Based Medicine, “Ivermectin is the New Hydroxychloroquine” There has been interest in ivermectin since the early days of the COVID-19 pandemic, because it was observed that at high concentrations it had antiviral properties against the SARS-CoV-2 virus. However, there was an important red flag in that finding. A few weeks after the initial finding was published, a short paper appeared in the British Journal of Clinical Pharmacology that described the considerations for using ivermectin as an antiviral. While it acknowledged the antiviral properties of high concentrations of the drug in laboratory (in vitro) experiments, it noted that it would likely not be possible to achieve the same concentrations of the drug in the plasma of the blood, because the drug itself is tightly bound to blood p