In this episode we discuss acute alcohol intoxication and withdrawal. We go into the pathophysiology of EtOH intoxication, a common approach to patients with intoxication and withdrawal, and an approach to management plans. Finally, we finish off by discussing the JAMA rational clinical exam article "Will this Hospitalized Patient Develop Severe Alcohol Withdrawal Syndrome?”. Written by Dr. Nikita-Kiran Singh (internal medicine resident) and edited by Dr. Peter Wu, Internal Medicine and Clinical Pharmacology/Toxicology specialist, and Dr. Gillian Spiegle, General Internal Medicine specialist. Infographic by Dr. Caitlyn Vlasschaert.