Educational Pearls Truvada (Emtricitabine/tenofovir) is a combination nucleotide reverse transcriptase inhibitor that can be used as pre-exposure prophylaxis (PrEP) for HIV. It has been shown to dramatically reduce the risk of contracting HIV. It is used in high-risk patients, like the MSM community or those who are in a relationship with someone with HIV. Side effects include nausea, vomiting, headache, and liver damage. HIV testing should be performed every 3 months while taking it, since it is not meant to fight an actual infection. Since 2012, there have only been 3 confirmed cases of transmission while using Truvada. It costs between 50-60$ dollars per pill, but it is covered by most insurances, including Medicaid. Generic version has recently been FDA approved. References: https://www.cdc.gov/hiv/pdf/prep_gl_patient_factsheet_truvada_english.pdf